Crispini Alessandra, Aiello Iolinda, Godbert Nicolas, La Deda Massimo, di Maio Giuseppe, Tagarelli Antonio, Elliani Rosangela, De Rose Renata, Scarpelli Francesca
MAT-InLAB, LASCAMM CR-INSTM, Unità INSTM della Calabria, Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, 87036, Arcavacata di Rende, CS, Italy.
LPM-Laboratorio Preparazione Materiali, Star-Lab, Università della Calabria, 87036, Arcavacata di Rende, CS, Italy.
Chemistry. 2024 Aug 6;30(44):e202400452. doi: 10.1002/chem.202400452. Epub 2024 Jul 18.
Bio-active ethylcellulose (EC) polymeric films have been obtained by incorporating curcumin (curc) and Ag(I)-based compounds, known for their antioxidant and antimicrobial activity, respectively, within the polymeric matrix. The recently reported Ag(I) coordination polymer, in both its structural forms (α-[(bpy)Ag(OTf)] and β-{[(bpy)Ag][OTf]}), and the [(bpy)Ag(OTf)]-curc polymeric co-crystal (bpy=2,2'-bipyridine; OTf=trifluoromethanesulfonate) have been selected as Ag(I) species. The hybrid composite films have been prepared through the simple solvent casting method and characterized through Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscope (SEM), UV-vis spectroscopy. The deep investigation of the film samples highlighted the non-inert behaviour of EC towards these specific active ingredients. Antimicrobial tests showed that EC films embedding the Ag(I)-based compounds present good antimicrobial performance, in particular against Staphylococcus aureus, used as a model of Gram-positive bacteria. In addition, Silver migration tests, performed on the Ag(I)-incorporating EC films, evidenced low values of silver release particularly in the case of the EC films incorporating [(bpy)Ag(OTf)]-curc.
通过将姜黄素（curc）和基于Ag（I）的化合物分别掺入聚合物基质中，制备了具有生物活性的乙基纤维素（EC）聚合物薄膜，已知它们分别具有抗氧化和抗菌活性。最近报道的Ag（I）配位聚合物，包括其两种结构形式（α-[(bpy)Ag(OTf)]和β-{[(bpy)Ag][OTf]}），以及[(bpy)Ag(OTf)]-curc聚合物共晶体（bpy = 2,2'-联吡啶；OTf = 三氟甲磺酸盐）已被选作Ag（I）物种。通过简单的溶剂浇铸法制备了混合复合薄膜，并通过粉末X射线衍射（PXRD）、差示扫描量热法（DSC）、傅里叶变换红外（FTIR）光谱、扫描电子显微镜（SEM）、紫外可见光谱对其进行了表征。对薄膜样品的深入研究突出了EC对这些特定活性成分的非惰性行为。抗菌测试表明，嵌入基于Ag（I）的化合物的EC薄膜具有良好的抗菌性能，特别是对用作革兰氏阳性菌模型的金黄色葡萄球菌。此外，对掺入Ag（I）的EC薄膜进行的银迁移测试表明，银释放值较低，特别是在掺入[(bpy)Ag(OTf)]-curc的EC薄膜的情况下。
