Division of Breast and Melanoma Surgical Oncology, Department of Surgery, Mayo Clinic, Rochester, Minnesota.
Division of Epidemiology, Biostatistics, and Preventive Medicine, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico.
Cancer Epidemiol Biomarkers Prev. 2024 Aug 1;33(8):1107-1113. doi: 10.1158/1055-9965.EPI-24-0204.
Although Hispanic White (HW) females have a lower incidence of breast cancer than non-Hispanic White (NHW) females, breast cancer risk is unclear for HW females after benign breast disease (BBD).
We compared BBD characteristics and subsequent breast cancer risk among HW and NHW females in New Mexico using a population-based collection of benign breast biopsies (1996-2007). BBD was categorized as nonproliferative disease (NPD), proliferative disease without atypia (PDWA), or atypical hyperplasia (AH). Breast cancer risk was assessed as absolute risk (AR) using cumulative incidence and RR by comparing the number of breast cancer events in BBDs to non-BBD.
This study included 3,684 HW and 6,587 NHW females with BBD. HW females had similar proportions of NPD (58.6% vs. 54.3%), PDWA (21.4% vs. 23.5%), and AH (3.6% vs. 3.3%) as NHW females. Breast cancer risk among all females with BBD was higher than population-based expected rates (RR, 1.87) and was similar for HW and NHW subgroups (RR = 1.99 vs. 1.84). As expected, breast cancer risk increased with increasing BBD severity, both overall [RR, 1.81 (NPD), 1.85 (PDWA), and 3.10 (AH)] and in the HW and NHW subgroups. Adjusted AR of breast cancer at 5 years also increased with the severity of BBD (HW vs. NHW; NPD: 1.4% vs. 2.1%; PDWA: 1.5% vs. 2.7%; AH: 6% vs. 4.8%).
We found similar breast cancer RRs and ARs in HW and NHW. Risk counseling should ensure that HW females receive breast cancer clinical management warranted by their similar absolute risks.
The present population-based provides evidence for the clinical management of HW females with BBD for the prevention of breast cancer.
尽管西班牙裔白人（HW）女性的乳腺癌发病率低于非西班牙裔白人（NHW）女性，但 HW 女性在良性乳腺疾病（BBD）后的乳腺癌风险尚不清楚。
我们使用基于人群的良性乳腺活检数据库（1996-2007 年），比较了新墨西哥州 HW 和 NHW 女性的 BBD 特征和随后的乳腺癌风险。BBD 分为非增殖性疾病（NPD）、非典型增生前增殖性疾病（PDWA）或非典型性增生（AH）。使用累积发病率和 RR 比较 BBD 与非 BBD 的乳腺癌事件数，评估乳腺癌风险为绝对风险（AR）。
本研究纳入了 3684 名 HW 和 6587 名 NHW 女性的 BBD。HW 女性的 NPD（58.6% vs. 54.3%）、PDWA（21.4% vs. 23.5%）和 AH（3.6% vs. 3.3%）的比例与 NHW 女性相似。所有患有 BBD 的女性的乳腺癌风险均高于基于人群的预期率（RR，1.87），HW 和 NHW 亚组的风险相似（RR=1.99 vs. 1.84）。正如预期的那样，随着 BBD 严重程度的增加，整体乳腺癌风险也会增加[RR，1.81（NPD）、1.85（PDWA）和 3.10（AH）]，HW 和 NHW 亚组也是如此。调整后的 5 年乳腺癌 AR 也随 BBD 严重程度的增加而增加（HW 与 NHW；NPD：1.4% vs. 2.1%；PDWA：1.5% vs. 2.7%；AH：6% vs. 4.8%）。
我们发现 HW 和 NHW 的乳腺癌 RR 和 AR 相似。风险咨询应确保 HW 女性接受与其相似的绝对风险相称的乳腺癌临床管理。
本基于人群的研究为 HW 女性 BBD 的乳腺癌预防提供了临床管理依据。
