Byrne Celia, Webb Penelope M, Jacobs Timothy W, Peiro Gloria, Schnitt Stuart J, Connolly James L, Willett Walter C, Colditz Graham A
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School Boston, Massachusetts 02115, USA.
Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1369-74.
We evaluated whether moderate alcohol consumption is associated with increased risk of developing benign breast disease (BBD), a potential "precursor" or marker for breast cancer development. This study evaluated associations between reported alcohol consumption and BBD diagnosis among 75,826 women in the Nurses' Health Study II. Between 1989 and 1997, 16,035 women reported a first diagnosis of BBD (317/10,000 person-years), of which 2,999 diagnoses were confirmed by tissue biopsy (59/10,000 person-years). Of the pathology specimens reviewed, 532 were nonproliferative benign breast conditions, and 932 were proliferative conditions. Person-time models provided estimates of the rate ratio (RR) and 95% confidence interval (CI). Reported recent adult consumption of alcohol was not associated with increased BBD incidence. Compared with women who did not drink alcohol, the age- and body mass index (BMI)-adjusted RRs for any reported BBD were 0.98 (95% CI, 0.95-1.02) for those who consumed <5 g/day, 0.93 (95% CI, 0.89-0.98) for those who consumed 5-14.9 g/day, and 0.90 (95% CI, 0.83-0.98) for those who consumed >or=15 g/day. The adjusted RRs for biopsy confirmed BBD and any proliferative benign condition were similiar. However, reported alcohol consumption of >or=15 g/day between ages 18 and 22 years was associated with higher rates of biopsy-confirmed BBD (age- and body mass index-adjusted RR = 1.14; 95% CI, 1.00-1.30), nonproliferative BBD (RR = 1.46; 95% CI, 1.09-1.96), and any proliferative BBD (RR = 1.33; 95% CI, 1.05-1.69), but not atypical hyperplasia. In this study, recent alcohol consumption was associated with slightly lower rates of reported BBD. However, greater alcohol consumption earlier in life (ages 18-22 years) was associated with higher proliferative BBD rates, suggesting that timing of exposure may be relevant to disease incidence.
我们评估了适度饮酒是否与患良性乳腺疾病（BBD）风险增加相关，BBD是乳腺癌发生的一种潜在“前驱病变”或标志物。本研究评估了护士健康研究II中75826名女性报告的饮酒情况与BBD诊断之间的关联。1989年至1997年间，16035名女性报告首次诊断为BBD（317/10000人年），其中2999例诊断经组织活检证实（59/10000人年）。在审查的病理标本中，532例为非增殖性良性乳腺疾病，932例为增殖性疾病。人时模型提供了率比（RR）和95%置信区间（CI）的估计值。报告的近期成年饮酒量与BBD发病率增加无关。与不饮酒的女性相比，对于任何报告的BBD，每天饮酒量<5克者经年龄和体重指数（BMI）调整后的RR为0.98（95%CI，0.95 - 1.02），每天饮酒量5 - 14.9克者为0.93（95%CI，0.89 - 0.98），每天饮酒量≥15克者为0.
