Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea; Institute for Health and Society, Hanyang University, Seoul, South Korea.
Center for Cohort Studies, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.
Heart Lung. 2024 Sep-Oct;67:176-182. doi: 10.1016/j.hrtlng.2024.05.002. Epub 2024 Jun 4.
There is a growing amount of evidence on the association between cardiovascular diseases (CVDs) and breast calcification. Thus, mammographic breast features have recently gained attention as CVD predictors.
This study assessed the association of mammographic features, including benign calcification, microcalcification, and breast density, with cardiovascular diseases.
This study comprised 6,878,686 women aged ≥40 who underwent mammographic screening between 2009 and 2012 with follow-up until 2020. The mammographic features included benign calcification, microcalcification, and breast density. The cardiovascular diseases associated with the mammographic features were assessed using logistic regression.
The prevalence of benign calcification, microcalcification, and dense breasts were 9.6 %, 0.9 % and 47.3 % at baseline, respectively. Over a median follow-up of 10 years, benign calcification and microcalcification were positively associated with an increased risk of chronic ischaemic heart disease whereas breast density was inversely associated with it; the corresponding aOR (95 % CI) was 1.14 (1.10-1.17), 1.19 (1.03-1.15), and 0.88 (0.85-0.90), respectively. A significantly increased risk of chronic ischaemic heart disease (IHD) was observed among women with benign calcifications (aHR, 1.14; 95 % CI 1.10-1.17) and microcalcifications (aOR, 1.19; 95 % CI 1.06-1.33). Women with microcalcifications had a 1.16-fold (95 % CI 1.03-1.30) increased risk of heart failure.
Mammographic calcifications were associated with an increased risk of chronic ischaemic heart diseases, whereas dense breast was associated with a decreased risk of cardiovascular disease. Thus, the mammographic features identified on breast cancer screening may provide an opportunity for cardiovascular disease risk identification and prevention.
心血管疾病（CVDs）与乳腺钙化之间的关联有大量证据。因此，乳腺影像学特征最近作为 CVD 预测因子受到关注。
本研究评估了乳腺影像学特征（包括良性钙化、微钙化和乳腺密度）与心血管疾病的关系。
本研究纳入了 2009 年至 2012 年期间接受乳腺 X 线筛查且随访至 2020 年的 6878686 名年龄≥40 岁的女性。乳腺影像学特征包括良性钙化、微钙化和乳腺密度。使用 logistic 回归评估与乳腺影像学特征相关的心血管疾病。
基线时良性钙化、微钙化和致密乳腺的患病率分别为 9.6%、0.9%和 47.3%。在中位随访 10 年期间，良性钙化和微钙化与慢性缺血性心脏病风险增加相关，而乳腺密度则与之呈负相关；相应的校正比值比（95%CI）分别为 1.14（1.10-1.17）、1.19（1.03-1.15）和 0.88（0.85-0.90）。良性钙化（aHR，1.14；95%CI 1.10-1.17）和微钙化（aOR，1.19；95%CI 1.06-1.33）的女性患慢性缺血性心脏病的风险显著增加。微钙化的女性患心力衰竭的风险增加 1.16 倍（95%CI 1.03-1.30）。
乳腺钙化与慢性缺血性心脏病风险增加相关，而致密乳腺与心血管疾病风险降低相关。因此，乳腺癌筛查中识别的乳腺影像学特征可能为识别和预防心血管疾病风险提供机会。
