Army Health and Performance Research, Army Headquarters, Andover, United Kingdom; Division of Surgery and Interventional Science, UCL, London, United Kingdom.
Army Health and Performance Research, Army Headquarters, Andover, United Kingdom.
Bone. 2024 Sep;186:117145. doi: 10.1016/j.bone.2024.117145. Epub 2024 Jun 3.
The influence of iron on collagen synthesis and vitamin D metabolism has implications for bone health. This cross-sectional observational study investigated associations between markers of iron status and tibial structure, vitamin D metabolites, and circulating biochemical markers of bone metabolism in young healthy men. A total of 343 male British Army recruits participated (age 22 ± 3 y, height 1.77 ± 0.06 m, body mass 75.5 ± 10.1 kg). Circulating biochemical markers of iron status, vitamin D metabolites, and bone metabolism, and tibial structure and density by high-resolution peripheral quantitative computed tomography scans (HRpQCT) were measured in participants during week 1 of basic military training. Associations between markers of iron status and HRpQCT outcomes, bone metabolism, and vitamin D metabolites were tested, controlling for age, height, lean body mass, and childhood exercise volume. Higher ferritin was associated with higher total, trabecular, and cortical volumetric bone mineral density, trabecular volume, cortical area and thickness, stiffness, and failure load (all p ≤ 0.037). Higher soluble transferrin receptor (sTfR) was associated with lower trabecular number, and higher trabecular thickness and separation, cortical thickness, and cortical pore diameter (all p ≤ 0.033). Higher haemoglobin was associated with higher cortical thickness (p = 0.043). Higher ferritin was associated with lower βCTX, PINP, total 25(OH)D, and total 24,25(OH)D, and higher 1,25(OH)D:24,25(OH)D ratio (all p ≤ 0.029). Higher sTfR was associated with higher PINP, total 25(OH)D, and total 24,25(OH)D (all p ≤ 0.025). The greater density, size, and strength of the tibia, and lower circulating concentrations of markers of bone resorption and formation with better iron stores (higher ferritin) are likely as a result of the direct role of iron in collagen synthesis.
铁对胶原蛋白合成和维生素 D 代谢的影响与骨骼健康有关。这项横断面观察性研究调查了年轻健康男性的铁状态标志物与胫骨结构、维生素 D 代谢物以及循环骨代谢生化标志物之间的关系。共有 343 名英国陆军新兵参加了这项研究（年龄 22 ± 3 岁，身高 1.77 ± 0.06 米，体重 75.5 ± 10.1 公斤）。在基础军事训练的第一周，通过高分辨率外周定量计算机断层扫描（HRpQCT）测量了参与者的循环铁状态生化标志物、维生素 D 代谢物和骨代谢以及胫骨结构和密度。在控制年龄、身高、瘦体重和儿童期运动量的情况下，测试了铁状态标志物与 HRpQCT 结果、骨代谢和维生素 D 代谢物之间的关系。较高的铁蛋白与总骨密度、骨小梁和皮质骨体积、骨小梁体积、皮质面积和厚度、刚度和失效负荷较高有关（均 p ≤ 0.037）。较高的可溶性转铁蛋白受体（sTfR）与较低的骨小梁数量、较高的骨小梁厚度和分离、皮质厚度和皮质孔径有关（均 p ≤ 0.033）。较高的血红蛋白与较高的皮质厚度有关（p = 0.043）。较高的铁蛋白与较低的βCTX、PINP、总 25（OH）D 和总 24,25（OH）D 以及较高的 1,25（OH）D：24,25（OH）D 比值有关（均 p ≤ 0.029）。较高的 sTfR 与较高的 PINP、总 25（OH）D 和总 24,25（OH）D 有关（均 p ≤ 0.025）。更好的铁储存（更高的铁蛋白）与胫骨密度、大小和强度增加以及循环骨吸收和形成标志物浓度降低有关，这可能是由于铁在胶原蛋白合成中的直接作用。
