State Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, China; Medical Research Institute, Southwest University, Chongqing 400715, China.
Medical Research Institute, Southwest University, Chongqing 400715, China.
Int J Biol Macromol. 2024 Jul;273(Pt 2):132867. doi: 10.1016/j.ijbiomac.2024.132867. Epub 2024 Jun 3.
Mounting an active immune response is energy intensive and demands the reallocation of nutrients to maintain the body's resistance and tolerance against infections. Central to this metabolic adaptation is Glucose-6-phosphate dehydrogenase (G6PDH), a housekeeping enzyme involve in pentose phosphate pathway (PPP). PPP play an essential role in generating ribose, which is critical for nicotinamide adenine dinucleotide phosphate (NADPH). It is vital for physiological and cellular processes such as generating nucleotides, fatty acids and reducing oxidative stress. The G6PDH is extremely conserved enzyme across species in PP shunt. The deficiency of enzymes leads to serious consequences on organism, particularly on adaptation and development. Acute deficiency can lead to impaired cell development, halted embryonic growth, reduce sensitivity to insulin, hypertension and increase inflammation. Historically, research focusing on G6PDH and PPP have primarily targeted diseases on mammalian. However, our review has investigated the unique functions of the G6PDH enzyme in insects and greatly improved mechanistic understanding of its operations. This review explore how G6PDH in insects plays a crucial role in managing the redox balance and immune related metabolism. This study aims to investigate the enzyme's role in different metabolic adaptations.
激发主动免疫反应需要消耗大量能量，并需要重新分配营养物质，以维持身体对感染的抵抗力和耐受性。葡萄糖-6-磷酸脱氢酶（G6PDH）是这种代谢适应的核心，它是参与磷酸戊糖途径（PPP）的一种管家酶。PPP 在生成核糖中起着至关重要的作用，核糖对烟酰胺腺嘌呤二核苷酸磷酸（NADPH）至关重要。它对于产生核苷酸、脂肪酸和减少氧化应激等生理和细胞过程至关重要。G6PDH 在 PPP 分流中是一种在物种间高度保守的酶。酶的缺乏会对生物体造成严重后果，特别是对适应和发育的影响。急性缺乏会导致细胞发育受损、胚胎生长停止、降低对胰岛素的敏感性、高血压和增加炎症。从历史上看，针对 G6PDH 和 PPP 的研究主要集中在哺乳动物的疾病上。然而，我们的综述调查了 G6PDH 在昆虫中的独特功能，并大大提高了对其运作的机制理解。本综述探讨了昆虫中的 G6PDH 如何在管理氧化还原平衡和与免疫相关的代谢中发挥关键作用。本研究旨在研究该酶在不同代谢适应中的作用。
