Université Lyon, Université Claude Bernard Lyon 1, CNRS, INSA Lyon, UMR5240 MAP Lyon, France.
CNRS, Aix-Marseille Université, Laboratoire de Chimie Bactérienne, UMR7283, IMM, IM2B, F-13009 Marseille, France.
RNA. 2024 Aug 16;30(9):1107-1121. doi: 10.1261/rna.080010.124.
ArcZ is a small regulatory RNA conserved in It is an Hfq-dependent RNA that is cleaved by RNase E in a processed form of 55-60 nucleotides. This processed form is highly conserved for controlling the expression of target mRNAs. ArcZ expression is induced by abundant oxygen levels and reaches its peak during the stationary growth phase. This control is mediated by the oxygen-responsive two-component system ArcAB, leading to the repression of transcription under low-oxygen conditions in most bacteria in which it has been studied. ArcZ displays multiple targets, and it can control up to 10% of a genome and interact directly with more than 300 mRNAs in and ArcZ displays a multifaceted ability to regulate its targets through diverse mechanisms such as RNase recruitment, modulation of ribosome accessibility on the mRNA, and interaction with translational enhancing regions. By influencing stress response, motility, and virulence through the regulation of master regulators such as FlhDC or RpoS, ArcZ emerges as a major orchestrator of cell physiology within .
ArcZ 是一种在 中保守的小调控 RNA。它是一种依赖于 Hfq 的 RNA，在 55-60 个核苷酸的加工形式中被 RNase E 切割。这种加工形式高度保守，用于控制靶 mRNA 的表达。ArcZ 的表达受丰富的氧气水平诱导，并在静止生长阶段达到峰值。这种控制是由氧响应的双组分系统 ArcAB 介导的，导致在大多数已研究的细菌中，在低氧条件下抑制 转录。ArcZ 显示出多个靶标，它可以控制多达 10%的基因组，并直接与 和 中的 300 多个 mRNA 相互作用。ArcZ 通过多种机制（如招募 RNase、调节 mRNA 上核糖体的可及性以及与翻译增强区域相互作用）来调节其靶标，显示出多方面的调节能力。通过调节 FlhDC 或 RpoS 等主调控因子来影响应激反应、运动性和毒力，ArcZ 成为 中细胞生理学的主要协调者。
