Ballantyne G H, Burke J B, Rogers G, Lampert E G, Boccia J
Ann Surg. 1985 Mar;201(3):360-4. doi: 10.1097/00000658-198503000-00019.
The healing of 3-cm longitudinal colotomies closed with either Czerny-Lembert suture lines (CLSL) or TA-30 staple lines (SSL) were studied in 28 mongrel dogs using bursting strength (BS) measurements. Dogs from each group were sacrificed on postoperative days (POD) 1 through 7. Mean BS for the SSL in all 14 dogs was 165 mmHg +/- 64 and for CLSL 80 mmHg +/- 49 (DF = 13; t = 5.5672; p less than 0.00005 for matched pairs). For POD 2 through 5, BS of the SSL was 154 mmHg +/- 42, three times greater than the BS of the CSLS, which was 54 mmHg +/- 33 (DF = 7; t = 5.6289; p less than 0.0004 for matched pairs). BS of the SSL increased linearly from the first day of surgery: BS (mmHg) = 26 (POD) + 61 (n = 14; r = 0.838; p less than 0.01). BS of the CLSL followed the traditional pattern of wound healing dropping to a nadir after 3 days and then increasing linearly: BS (mmHg) = 32 (POD) - 72 (n = 10; r = 0.834; p less than 0.01). Microscopic examination revealed a greater inflammatory response to the CSLS than the SSL. Differences were most marked from 2 to 4 days following operation. Thus, the SSL healed more rapidly than the CLSL as measured by BS. The SSL healed with a negligible Lag Period of wound healing entering directly into the Period of Fibroplasia.
在28只杂种犬中，通过测量爆破强度（BS）研究了采用Czerny-Lembert缝合线（CLSL）或TA-30吻合钉线（SSL）闭合3厘米纵向结肠切开术的愈合情况。每组的犬在术后第1天至第7天处死。所有14只接受SSL缝合的犬的平均BS为165 mmHg±64，接受CLSL缝合的犬为80 mmHg±49（自由度=13；t=5.5672；配对比较p<0.00005）。在术后第2天至第5天，SSL的BS为154 mmHg±42，是CLSL的BS（54 mmHg±33）的三倍（自由度=7；t=5.6289；配对比较p<0.0004）。SSL的BS从手术第一天开始呈线性增加：BS（mmHg）=26（术后天数）+61（n=14；r=0.838；p<0.01）。CLSL的BS遵循传统的伤口愈合模式，在3天后降至最低点，然后呈线性增加：BS（mmHg）=32（术后天数）-72（n=10；r=0.834；p<0.01）。显微镜检查显示，与SSL相比，CLSL引发的炎症反应更强。差异在术后2至4天最为明显。因此，以BS衡量，SSL的愈合速度比CLSL更快。SSL愈合时伤口愈合延迟期可忽略不计，直接进入纤维增生期。
