Medicine, University of Florida, Gainesville, Florida, USA
University of Florida, Gainesville, Florida, USA.
BMJ Case Rep. 2024 Jun 5;17(6):e258580. doi: 10.1136/bcr-2023-258580.
Paraneoplastic pemphigus (PNP) is a rare disease with an unclear mechanism of pathogenesis. We present a case of a male patient who presented with wound management after being diagnosed with Castleman disease-associated paraneoplastic pemphigus (PNP). The patient's condition was not improving; as a result, extensive workup was repeated, which confirmed the diagnosis of aggressive T cell lymphoblastic lymphoma. Our case signifies the importance of keeping a high index of suspicion for PNP-associated malignancies. This case report also adds emphasis to the diagnostic challenges faced by clinicians, making clinical correlation with multidisciplinary approach essential. Therefore, if clinically indicated, we need to revisit the diagnosis and seek alternative explanations to prevent delays in management.
副肿瘤天疱疮（PNP）是一种发病机制尚不清楚的罕见疾病。我们报告了一例男性患者，该患者在诊断为伴副肿瘤天疱疮（PNP）的Castleman 病后接受伤口处理。患者的病情没有改善；因此，反复进行了广泛的检查，最终确诊为侵袭性 T 细胞淋巴母细胞淋巴瘤。我们的病例表明，对 PNP 相关恶性肿瘤保持高度怀疑的重要性。本病例报告还强调了临床医生面临的诊断挑战，因此临床相关性和多学科方法至关重要。因此，如果临床上有指征，我们需要重新考虑诊断并寻找其他解释，以避免治疗延误。
