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父亲的饮食通过精子 RNA 影响儿子的代谢健康。

Father's diet influences son's metabolic health through sperm RNA.

出版信息

Nature. 2024 Jun;630(8017):571-573. doi: 10.1038/d41586-024-01502-w.

DOI:10.1038/d41586-024-01502-w
PMID:38839997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11573352/
Abstract

DNA from organelles called mitochondria is not inherited from the father. But mitochondrial RNAs that sense paternal diet and mitochondrial quality are delivered from sperm to egg, affecting offspring metabolism.

摘要

来自被称为线粒体的细胞器的 DNA 不是从父亲那里遗传的。但是，能够感知父系饮食和线粒体质量的线粒体 RNA 是从精子传递到卵子的，这会影响后代的新陈代谢。

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本文引用的文献

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2
tRNA renovatio: Rebirth through fragmentation.tRNA 修复：通过断裂实现重生。
Mol Cell. 2023 Nov 16;83(22):3953-3971. doi: 10.1016/j.molcel.2023.09.016. Epub 2023 Oct 5.
3
Molecular basis for maternal inheritance of human mitochondrial DNA.人类线粒体 DNA 母系遗传的分子基础。
通过PANDORA-seq揭示的阿尔茨海默病小鼠模型中与溶酶体活性增加相关的线粒体小RNA改变
Int J Mol Sci. 2025 Mar 26;26(7):3019. doi: 10.3390/ijms26073019.
4
Optimized identification and characterization of small RNAs with PANDORA-seq.利用PANDORA-seq对小RNA进行优化鉴定和表征。
Nat Protoc. 2025 Apr 3. doi: 10.1038/s41596-025-01158-4.
5
Mitochondrial small RNA alterations associated with increased lysosome activity in an Alzheimer's Disease Mouse Model uncovered by PANDORA-seq.通过PANDORA-seq发现的阿尔茨海默病小鼠模型中与溶酶体活性增加相关的线粒体小RNA改变。
bioRxiv. 2024 Oct 22:2024.10.18.619155. doi: 10.1101/2024.10.18.619155.
6
tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators.tRNA 和 tsRNA：从异质性到多功能调控因子。
Biomolecules. 2024 Oct 21;14(10):1340. doi: 10.3390/biom14101340.
7
Paternal hypercholesterolemia elicits sex-specific exacerbation of atherosclerosis in offspring.父代高胆固醇血症可导致子代发生具有性别特异性的动脉粥样硬化恶化。
JCI Insight. 2024 Sep 10;9(17):e179291. doi: 10.1172/jci.insight.179291.
Nat Genet. 2023 Oct;55(10):1632-1639. doi: 10.1038/s41588-023-01505-9. Epub 2023 Sep 18.
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6
Exploring the expanding universe of small RNAs.探索小RNA不断扩展的世界。
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