父亲的饮食通过精子 RNA 影响儿子的代谢健康。
Father's diet influences son's metabolic health through sperm RNA.
出版信息
Nature. 2024 Jun;630(8017):571-573. doi: 10.1038/d41586-024-01502-w.
Abstract
DNA from organelles called mitochondria is not inherited from the father. But mitochondrial RNAs that sense paternal diet and mitochondrial quality are delivered from sperm to egg, affecting offspring metabolism.
摘要
来自被称为线粒体的细胞器的 DNA 不是从父亲那里遗传的。但是，能够感知父系饮食和线粒体质量的线粒体 RNA 是从精子传递到卵子的，这会影响后代的新陈代谢。
相似文献
1
Father's diet influences son's metabolic health through sperm RNA.父亲的饮食通过精子 RNA 影响儿子的代谢健康。
Nature. 2024 Jun;630(8017):571-573. doi: 10.1038/d41586-024-01502-w.
2
Reciprocal influence of parent discipline and child's behavior on risk for substance use disorder: a nine-year prospective study.父母管教与孩子行为对物质使用障碍风险的相互影响：一项为期九年的前瞻性研究。
Am J Drug Alcohol Abuse. 2007;33(6):851-67. doi: 10.1080/00952990701653842.
3
Obese father's metabolic state, adiposity, and reproductive capacity indicate son's reproductive health.肥胖父亲的代谢状态、肥胖程度和生殖能力预示着儿子的生殖健康。
Fertil Steril. 2014 Mar;101(3):865-73. doi: 10.1016/j.fertnstert.2013.12.007. Epub 2014 Jan 11.
4
Sperm microRNA Content Is Altered in a Mouse Model of Male Obesity, but the Same Suite of microRNAs Are Not Altered in Offspring's Sperm.在雄性肥胖小鼠模型中精子微小RNA含量发生改变，但同一组微小RNA在子代精子中未发生改变。
PLoS One. 2016 Nov 4;11(11):e0166076. doi: 10.1371/journal.pone.0166076. eCollection 2016.
5
Father and adolescent son variables related to son's HIV prevention.与儿子的艾滋病病毒预防相关的父亲及青少年儿子的变量。
West J Nurs Res. 2008 Feb;30(1):73-89; discussion 90-5. doi: 10.1177/0193945906296554. Epub 2007 Jul 18.
6
Associations of middle-aged mother's but not father's body mass index with 18-year-old son's waist circumferences, birth weight, and serum hepatic enzyme levels.中年母亲而非父亲的体重指数与18岁儿子的腰围、出生体重及血清肝酶水平之间的关联。
Metabolism. 2005 Apr;54(4):466-70. doi: 10.1016/j.metabol.2004.10.014.
7
Father's rights not infringed by son's mandatory health class.儿子的必修课健康课程未侵犯父亲的权利。
AIDS Policy Law. 2002 May 10;17(9):6.
8
Father's family violence and son's delinquency: conflict tactics, bonding, and serious juvenile crime in the Mexican-American family.父亲的家庭暴力与儿子的犯罪行为：墨西哥裔美国家庭中的冲突策略、情感联结与严重青少年犯罪
West J Nurs Res. 1990 Oct;12(5):682-3. doi: 10.1177/019394599001200509.
9
Father's family violence and son's delinquency. Conflict tactics, bonding, and serious juvenile crime in the Mexican-American family.父亲的家庭暴力与儿子的犯罪行为。墨西哥裔美国家庭中的冲突策略、情感纽带与严重青少年犯罪
West J Nurs Res. 1990 Feb;12(1):60-70; discussion 70-4. doi: 10.1177/019394599001200105.
10
HPV vaccination in Japan: can educational intervention promote a father's intention to encourage his daughter's vaccination?日本的 HPV 疫苗接种：教育干预能否促进父亲鼓励女儿接种疫苗的意愿？
Int J Clin Oncol. 2020 Apr;25(4):746-754. doi: 10.1007/s10147-019-01575-y. Epub 2019 Nov 12.
引用本文的文献
1
Genetic and epigenetic landscape of male infertility.男性不育的遗传和表观遗传格局
Trends Genet. 2025 Aug 21. doi: 10.1016/j.tig.2025.07.007.
2
Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational Health.精子中氧化还原驱动的表观遗传修饰：揭示父系对胚胎发育和跨代健康的影响
Antioxidants (Basel). 2025 May 9;14(5):570. doi: 10.3390/antiox14050570.
3
Mitochondrial Small RNA Alterations Associated with Increased Lysosome Activity in an Alzheimer's Disease Mouse Model Uncovered by PANDORA-seq.通过PANDORA-seq揭示的阿尔茨海默病小鼠模型中与溶酶体活性增加相关的线粒体小RNA改变
Int J Mol Sci. 2025 Mar 26;26(7):3019. doi: 10.3390/ijms26073019.
4
Optimized identification and characterization of small RNAs with PANDORA-seq.利用PANDORA-seq对小RNA进行优化鉴定和表征。
Nat Protoc. 2025 Apr 3. doi: 10.1038/s41596-025-01158-4.
5
Mitochondrial small RNA alterations associated with increased lysosome activity in an Alzheimer's Disease Mouse Model uncovered by PANDORA-seq.通过PANDORA-seq发现的阿尔茨海默病小鼠模型中与溶酶体活性增加相关的线粒体小RNA改变。
bioRxiv. 2024 Oct 22:2024.10.18.619155. doi: 10.1101/2024.10.18.619155.
6
tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators.tRNA 和 tsRNA：从异质性到多功能调控因子。
Biomolecules. 2024 Oct 21;14(10):1340. doi: 10.3390/biom14101340.
7
Paternal hypercholesterolemia elicits sex-specific exacerbation of atherosclerosis in offspring.父代高胆固醇血症可导致子代发生具有性别特异性的动脉粥样硬化恶化。
JCI Insight. 2024 Sep 10;9(17):e179291. doi: 10.1172/jci.insight.179291.
本文引用的文献
1
Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs.饮食诱导和精子携带的线粒体 RNA 的表观遗传遗传。
Nature. 2024 Jun;630(8017):720-727. doi: 10.1038/s41586-024-07472-3. Epub 2024 Jun 5.
2
tRNA renovatio: Rebirth through fragmentation.tRNA 修复：通过断裂实现重生。
Mol Cell. 2023 Nov 16;83(22):3953-3971. doi: 10.1016/j.molcel.2023.09.016. Epub 2023 Oct 5.
3
Molecular basis for maternal inheritance of human mitochondrial DNA.人类线粒体 DNA 母系遗传的分子基础。
Nat Genet. 2023 Oct;55(10):1632-1639. doi: 10.1038/s41588-023-01505-9. Epub 2023 Sep 18.
4
Emerging functional principles of tRNA-derived small RNAs and other regulatory small RNAs.转运RNA衍生的小RNA及其他调控性小RNA的新兴功能原理
J Biol Chem. 2023 Oct;299(10):105225. doi: 10.1016/j.jbc.2023.105225. Epub 2023 Sep 9.
5
Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm.饮食中的糖会改变精子中线粒体代谢和小 RNA 的生物发生。
Antioxid Redox Signal. 2023 Jun;38(16-18):1167-1183. doi: 10.1089/ars.2022.0049. Epub 2023 Feb 23.
6
Exploring the expanding universe of small RNAs.探索小RNA不断扩展的世界。
Nat Cell Biol. 2022 Apr;24(4):415-423. doi: 10.1038/s41556-022-00880-5. Epub 2022 Apr 12.
7
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications.PANDORA-seq 通过克服 RNA 修饰来扩展调控性小 RNA 的 repertoire。
Nat Cell Biol. 2021 Apr;23(4):424-436. doi: 10.1038/s41556-021-00652-7. Epub 2021 Apr 5.
8
Human sperm displays rapid responses to diet.人类精子对饮食有快速反应。
PLoS Biol. 2019 Dec 26;17(12):e3000559. doi: 10.1371/journal.pbio.3000559. eCollection 2019 Dec.
9
Sperm RNA code programmes the metabolic health of offspring.精子 RNA 为后代的代谢健康设定了代码。
Nat Rev Endocrinol. 2019 Aug;15(8):489-498. doi: 10.1038/s41574-019-0226-2. Epub 2019 Jun 24.
10
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.Dnmt2 通过精子小非编码 RNA 介导亲代获得的代谢紊乱的跨代传递。
Nat Cell Biol. 2018 May;20(5):535-540. doi: 10.1038/s41556-018-0087-2. Epub 2018 Apr 25.
Zotero 插件