Jakobsen H, Hertz J B, Johansen J R, Hansen A, Kølliker K
Br J Anaesth. 1985 Mar;57(3):300-5. doi: 10.1093/bja/57.3.300.
Premedication with diazepam 0.25 mg kg-1 by mouth was compared with placebo in a double-blind trial in patients undergoing day-case surgery under general anaesthesia. Diazepam decreased significantly preoperative discomfort and apprehension. The patients were discharged on time regardless of the type of premedication, and complaints at the time of discharge and on the following day could be related only to the length of anaesthesia and not to the type of premedication. Premedication given early in the morning remained effective for up to 6 h.
在一项双盲试验中，对全身麻醉下行日间手术的患者口服0.25 mg/kg地西泮进行术前用药，并与安慰剂进行比较。地西泮显著降低了术前不适和焦虑。无论术前用药类型如何，患者均按时出院，出院时及次日的投诉仅与麻醉时长有关，与术前用药类型无关。清晨给予的术前用药效果可持续长达6小时。
