伴有米安色林依赖性抗体的血小板减少症和白细胞减少症。
Thrombocytopenia and leucopenia with mianserin-dependent antibodies.
作者信息
Stricker B H, Barendregt J N, Claas F H
出版信息
Br J Clin Pharmacol. 1985 Jan;19(1):102-4. doi: 10.1111/j.1365-2125.1985.tb02621.x.
By indirect immunofluorescence specific mianserin-dependent antibodies were detected against platelets but not against granulocytes in the serum of a patient with thrombocytopenic purpura and mild leucopenia. A complement-mediated cytotoxicity assay demonstrated 70% lysis of granulocytes but no lysis of platelets, only when mianserin was added to the medium. We suggest that, at least in some patients, mianserin may cause blood disorders by an immunologically-mediated mechanism.
通过间接免疫荧光法，在一名患有血小板减少性紫癜和轻度白细胞减少症的患者血清中检测到了针对血小板的特异性米安色林依赖性抗体，但未检测到针对粒细胞的此类抗体。补体介导的细胞毒性试验表明，仅在向培养基中添加米安色林时，粒细胞有70%发生裂解，而血小板未发生裂解。我们认为，至少在某些患者中，米安色林可能通过免疫介导机制导致血液系统疾病。
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