Sharkey Brandon, Conner Kaitlin Michelle, McGarvey Cade R, Nair Ajay, Dorn Abbigail, Reinard Kevin, Gabel Brandon
Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States.
Department of Neurosurgery, Promedica Toledo Hospital, Toledo, Ohio, United States.
Surg Neurol Int. 2024 May 17;15:162. doi: 10.25259/SNI_794_2023. eCollection 2024.
Neuroblastomas are rare tumors activated by the gene commonly found in pediatric patients. Due to the novelty of these tumors, there is no standard diagnostic profile. However, they have been found to express , and synaptophysin, and they can be identified with magnetic resonance imaging (MRI). Treatment with chemotherapy combined with stem cell rescue and craniospinal irradiation can improve non-infant patient outcomes.
We report a case of a 2-year-old patient who was diagnosed with a neuroblastoma through MRI imaging and pathology that confirmed gene activation. The tumor was successfully removed. However, the tumor was not high-grade like most neuroblastomas.
The unusual presentation of a low-grade neuroblastoma demonstrates the necessity to conduct further research into the characteristics of these tumors.
神经母细胞瘤是一种罕见的肿瘤，常见于儿科患者，由该基因激活。由于这些肿瘤的新颖性，尚无标准的诊断特征。然而，已发现它们表达 、突触素，并且可以通过磁共振成像（MRI）进行识别。化疗联合干细胞救援和颅脊髓照射治疗可改善非婴儿患者的预后。
我们报告一例2岁患者，通过MRI成像和病理检查确诊为神经母细胞瘤，证实了该基因激活。肿瘤被成功切除。然而，该肿瘤不像大多数神经母细胞瘤那样为高级别。
低级别神经母细胞瘤的不寻常表现表明有必要对这些肿瘤的特征进行进一步研究。
