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恩宾宁在腰椎间盘突出症髓核重吸收中的作用：促进髓核新生血管形成及髓核细胞凋亡。

Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells.

作者信息

Meng Yingying, Liu Wei, Liu Haifeng, Yu Chengwei

机构信息

Department of Acupuncture and Moxibustion Massage, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang Province, 325000, China.

Department of Rehabilitation, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang Province, 325000, China.

出版信息

Open Life Sci. 2024 May 29;19(1):20220878. doi: 10.1515/biol-2022-0878. eCollection 2024.

DOI:10.1515/biol-2022-0878
PMID:38840893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11151393/
Abstract

Reabsorption of the nucleus pulposus (NP) in lumbar disc herniation (LDH) refers to the natural absorption or even complete disappearance of LDH. In order to better treat LDH, it is necessary to further study its mechanism and develop new therapeutic drugs. Clematidis Radix Et Rhizoma is a ranunculus family plant which has multiple biological activities, and Embinin is one of its bioactive ingredients. However, its effects on LDH were unclear. In this study, the role of Embinin was investigated in LDH rat models. LDH model was established by lumbar epidural insertion of tail disc. Our results showed that Embinin promoted lumbar disc neovascularization, induced apoptosis of NP cells in LDH rats, and promoted lumbar disc resorption. Furthermore, mechanistic study showed that Embinin activated the cAMP pathway in the rat models. In conclusion, Embinin has the potential to serve as a drug for the treatment of LDH.

摘要

腰椎间盘突出症（LDH）中髓核（NP）的重吸收是指LDH的自然吸收甚至完全消失。为了更好地治疗LDH，有必要进一步研究其机制并开发新的治疗药物。威灵仙是一种具有多种生物活性的毛茛科植物，铁线莲苷是其生物活性成分之一。然而，其对LDH的影响尚不清楚。在本研究中，研究了铁线莲苷在LDH大鼠模型中的作用。通过腰椎硬膜外插入尾椎间盘建立LDH模型。我们的结果表明，铁线莲苷促进腰椎间盘新生血管形成，诱导LDH大鼠NP细胞凋亡，并促进腰椎间盘吸收。此外，机制研究表明，铁线莲苷在大鼠模型中激活了cAMP途径。总之，铁线莲苷有潜力作为治疗LDH的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/2b65039c3815/j_biol-2022-0878-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/496daff88f4a/j_biol-2022-0878-ga001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/c17bd94e71b3/j_biol-2022-0878-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/2be0c4ebccc8/j_biol-2022-0878-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/c0ce30702104/j_biol-2022-0878-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/2b65039c3815/j_biol-2022-0878-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/496daff88f4a/j_biol-2022-0878-ga001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/c17bd94e71b3/j_biol-2022-0878-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/2be0c4ebccc8/j_biol-2022-0878-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/c0ce30702104/j_biol-2022-0878-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3b2/11151393/2b65039c3815/j_biol-2022-0878-fig004.jpg

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本文引用的文献

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Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway.Sirt1通过抑制NF-κB炎症通路，保护小鼠免受1,25-二羟基维生素D缺乏诱导的椎间盘退变。
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Lumbar Disc Herniation: Diagnosis and Management.
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Antioxidative behavior of a2-macroglobulin in intervertebral disc degeneration.α2-巨球蛋白在椎间盘退变中的抗氧化行为。
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A Microstructure-Based Mechanistic Approach to Detect Degeneration Effects on Potential Damage Zones and Morphology of Young and Old Human Intervertebral Discs.一种基于微观结构的力学方法，用于检测退变对年轻和老年人体椎间盘潜在损伤区域及形态的影响。
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