Gokhale Vijayashree, Yadav Ponvijaya M, Mishra Mahabir P, Vineetha Giduturi Naga Lakshmi
From the Department of Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Indian J Dermatol. 2024 Mar-Apr;69(2):174-177. doi: 10.4103/ijd.ijd_680_23. Epub 2024 Apr 29.
We report a case of a 54-year-old female diagnosed with HIV and antiretroviral therapy (ART) for the same. Seven years ago, she suffered from fever, cough and weight loss, was diagnosed with pulmonary tuberculosis and also seropositive for HIV. She suffered from Herpes Zoster infection, after which her ART regimen was changed to TLD (tenofovir, lamivudine and dolutegravir). The patient presented with two episodes of pyoderma gangrenosum (PG), which were biopsy-proven, corresponding to a rise in CD4 counts above 500. She responded to glucocorticoids, both systemic and topical.
我们报告一例54岁女性,被诊断为HIV感染并接受抗逆转录病毒治疗(ART)。七年前,她出现发热、咳嗽和体重减轻,被诊断为肺结核,且HIV血清学检测呈阳性。她曾患带状疱疹感染,之后其ART方案改为TLD(替诺福韦、拉米夫定和多替拉韦)。该患者出现两例坏疽性脓皮病(PG),经活检证实,这与CD4细胞计数升至500以上有关。她对全身和局部使用的糖皮质激素均有反应。