Rathod Santosh P, Padhiar Bela B, Karia Umesh K, Shah Bela J
Deparment of Skin and V.D., B.J. Medical College, Civil Hospital, Ahmedabad, Gujarat, India.
Indian J Sex Transm Dis AIDS. 2011 Jul;32(2):114-7. doi: 10.4103/0253-7184.85418.
Pyoderma gangrenosum(PG) is a rare ulcerating inflammatory neutrophilic dermatosis. Genital involvement has been rarely reported. We report such a case of 24- year- old, male patient living with HIV/AIDS(PLHIV) who presented with progressive genital ulceration, not responding to oral antibiotics and aciclovir, gradually increasing in size over 15-18 months. Repeated biopsies showed acute on chronic inflammation. The lesion partially responded to oral and topical corticosteroids but soon increased in size after tapering the dosage of the steroids.Then patient was given Imiquimod 5% cream to be applied over the lesion once daily for 2-4 weeks. Lesion cleared completely in 4 weeks and is in remission since last 6 months. The case report highlights the successful use of topical Imiquimod 5% cream in the treatment of penile PG.
坏疽性脓皮病（PG）是一种罕见的溃疡性炎症性中性粒细胞性皮肤病。生殖器受累情况鲜有报道。我们报告了一例24岁的男性艾滋病病毒/艾滋病患者，该患者出现进行性生殖器溃疡，口服抗生素和阿昔洛韦治疗无效，在15至18个月内溃疡面积逐渐增大。多次活检显示为慢性炎症基础上的急性炎症。病变对口服和外用皮质类固醇有部分反应，但在逐渐减少类固醇剂量后，病变很快又增大。随后给予患者5%咪喹莫特乳膏，每天在病变部位涂抹一次，持续2至4周。病变在4周内完全清除，且在过去6个月中一直处于缓解状态。该病例报告强调了外用5%咪喹莫特乳膏在治疗阴茎PG方面的成功应用。
