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啤酒中黄曲霉毒素的流行情况与浓度:一项全球系统评价与荟萃分析及概率性健康风险评估

The prevalence and concentration of aflatoxins in beers: a global systematic review and meta-analysis and probabilistic health risk assessment.

作者信息

Fakhri Yadolah, Ranaei Vahid, Pilevar Zahra, Moradi Mahboobeh, Mahmoudizeh Amirhossein, Hemmati Fatemeh, Mousavi Khaneghah Amin

机构信息

Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

School of Health, Arak University of Medical Sciences, Arak, Iran.

出版信息

Int J Environ Health Res. 2025 Feb;35(2):521-539. doi: 10.1080/09603123.2024.2362816. Epub 2024 Jun 6.

Abstract

Mycotoxins have been identified as considerable contaminants in beer. The current investigation's concentration and prevalence of aflatoxins (AFs) in beer were meta-analyzed. The health risk of consumers was estimated through MOEs in the Monte Carlo simulation (MCS) model. The rank order of AFs in beer based on pooled prevalence was AFB1 (26.00%) > AFG1 (14.93%) > AFB2 (7.69%) > AFG2 (7.52%), In addition, the rank order of AFs in beer based on their pooled concentration was AFG1 (0.505 µg/l) > AFB1 (0.469 µg/l) > AFB2 (0.134 µg/l) > AFG2 (0.071 µg/l). The prevalence and concentration of AFs in beer in Malawi were higher than in other countries. The health risk assessment shows consumers in all countries, especially Malawi, Brazil, and Cameroon, are exposed to unacceptably health risks (MOEs <10,000). It is recommended to monitor levels of AFs in beer efficiently and implement control plans in order to decrease health risk of exposed population.

摘要

霉菌毒素已被确认为啤酒中的重要污染物。对当前调查中啤酒中黄曲霉毒素(AFs)的浓度和流行情况进行了荟萃分析。通过蒙特卡洛模拟(MCS)模型中的暴露量(MOE)估计消费者的健康风险。基于合并流行率,啤酒中AFs的排序为:黄曲霉毒素B1(AFB1,26.00%)>黄曲霉毒素G1(AFG1,14.93%)>黄曲霉毒素B2(AFB2,7.69%)>黄曲霉毒素G2(AFG2,7.52%)。此外,基于合并浓度,啤酒中AFs的排序为:AFG1(0.505μg/l)>AFB1(0.469μg/l)>AFB2(0.134μg/l)>AFG2(0.071μg/l)。马拉维啤酒中AFs的流行率和浓度高于其他国家。健康风险评估表明,所有国家的消费者,尤其是马拉维、巴西和喀麦隆的消费者,面临不可接受的健康风险(MOE<10,000)。建议有效监测啤酒中AFs的水平并实施控制计划,以降低暴露人群的健康风险。

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