Chesnut R W, Grey H M
Crit Rev Immunol. 1985;5(3):263-316.
In this review we will examine the characteristics of the various cell types which have been shown to present antigens to helper and proliferating T cells and explore what is known about the requirements for antigen presentation by these cells. Cell types to be discussed include mononuclear phagocytes from a variety of tissues as well as nonphagocytic cells such as Langerhans cells and dendritic cells. Special consideration will be given to the most recent group of cells to have demonstrated antigen-presenting capacity, B lymphocytes. Experiments exploring the processing and presentation of antigen by these different cell types will be presented. These results suggest that immunologically relevant antigen is endocytosed and at least partially degraded before proper presentation can occur. The role of molecules synthesized by the presenting cells, such as MHC antigens and cytokines, will be discussed in detail.
在这篇综述中，我们将研究已被证明能向辅助性T细胞和增殖性T细胞呈递抗原的各种细胞类型的特征，并探讨关于这些细胞进行抗原呈递所需条件的已知情况。将要讨论的细胞类型包括来自各种组织的单核吞噬细胞以及非吞噬细胞，如朗格汉斯细胞和树突状细胞。将特别关注最近已证明具有抗原呈递能力的一组细胞，即B淋巴细胞。将展示探索这些不同细胞类型对抗原的加工和呈递的实验。这些结果表明，在进行适当呈递之前，免疫相关抗原会被内吞并至少部分降解。将详细讨论呈递细胞合成的分子，如主要组织相容性复合体（MHC）抗原和细胞因子的作用。
