Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Arch Gynecol Obstet. 2023 Nov;308(5):1431-1446. doi: 10.1007/s00404-023-06964-3. Epub 2023 Feb 25.
To assess whether endometriosis (EMs) was related to systematic and/or local deviations of cluster of differentiation (CD)4 + T cells.
Until November 2022, we enrolled a total of 1363 EMs and 1564 healthy women from 32 studies who met the inclusion criteria.
After systematically retrieving the literature, we identified 1086 citations and 32 case-control studies were enrolled. Cumulative results suggested that there were insignificant deviations of CD4 + T cells during peripheral blood (PB) between EMs and healthy women (RR: - 0.83, I = 99%, p = 0.65), also no statistically significant difference was found between mild and severe EMs (RR: 3.19, I = 94%, p = 0.19). We also found insignificant deviations of CD4 + /CD8 + during PB between EMs and healthy women (RR: 0.09, I = 99%, p = 0.39), and between mild and severe EMs (RR: - 0.16, I = 99%, p = 0.29). The results might suggest that there was no significant correlation between EMs and systematic deviations of CD4 + T cells. When it came to local deviation during peritoneal fluid (PF), the polled results suggested that the frequency of CD4 + T cells during EMs was significantly lower than healthy women (RR: - 5.38, I = 93%, p = 0.01), and the ratio of CD4 + /CD8 + during EMs was significantly lower than healthy women (RR: - 0.13, I = 0%, p < 0.0001). However, there were insignificant deviations of CD4 + during PF between mild and severe EMs (RR: 1.65, I = 53%, p = 0.15), also there was an insignificant difference of CD4 + /CD8 + between mild and severe EMs (RR: - 0.09, I = 14%, p = 0.19). EMs might be closely related to local deviations of CD4 + T cells.
There was no obvious correlation between EMs and systematic deviations of CD4 + T cells, EMs might be closely related to local deviations of CD4 + T cells. Further study on the functional deviations and subpopulation distribution of CD4 + T cells is urgently needed.
评估子宫内膜异位症（EMs）是否与 CD4+T 细胞的系统性和/或局部偏差有关。
截至 2022 年 11 月，我们共纳入了 32 项研究中的 1363 例 EMs 患者和 1564 例健康女性，这些研究均符合纳入标准。
通过系统检索文献，我们共识别出 1086 篇引文，纳入了 32 项病例对照研究。累积结果表明，EMs 患者和健康女性的外周血（PB）中 CD4+T 细胞无明显偏差（RR：-0.83，I=99%，p=0.65），轻度和重度 EMs 之间也无统计学差异（RR：3.19，I=94%，p=0.19）。我们还发现，EMs 患者和健康女性的 PB 中 CD4+/CD8+无明显偏差（RR：0.09，I=99%，p=0.39），轻度和重度 EMs 之间也无统计学差异（RR：-0.16，I=99%，p=0.29）。这可能表明 EMs 与 CD4+T 细胞的系统性偏差之间没有显著相关性。当涉及到腹膜液（PF）中的局部偏差时，汇总结果表明，EMs 患者的 CD4+T 细胞频率明显低于健康女性（RR：-5.38，I=93%，p=0.01），并且 EMs 患者的 CD4+/CD8+比值明显低于健康女性（RR：-0.13，I=0%，p<0.0001）。然而，轻度和重度 EMs 之间的 PF 中 CD4+的偏差无统计学意义（RR：1.65，I=53%，p=0.15），并且轻度和重度 EMs 之间的 CD4+/CD8+也无统计学差异（RR：-0.09，I=14%，p=0.19）。EMs 可能与 CD4+T 细胞的局部偏差密切相关。
EMs 与 CD4+T 细胞的系统性偏差之间没有明显的相关性，EMs 可能与 CD4+T 细胞的局部偏差密切相关。需要进一步研究 CD4+T 细胞的功能偏差和亚群分布。
