Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, Bahia, Brazil.
Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
PLoS Negl Trop Dis. 2024 Jun 6;18(6):e0011877. doi: 10.1371/journal.pntd.0011877. eCollection 2024 Jun.
The spleen plays a pivotal role in the pathogenesis of visceral leishmaniasis. In severe forms of the disease, the spleen undergoes changes that can compromise its function in surveilling blood-circulating pathogens. In this study, we present an integrated analysis of the structural and gene expression alterations in the spleens of three patients with relapsing visceral leishmaniasis, two of whom were coinfected with HIV. Our findings reveal that the IL6 signaling pathway plays a significant role in the disorganization of the white pulp, while BCL10 and ICOSLG are associated with spleen organization. Patients coinfected with HIV and visceral leishmaniasis exhibited lower splenic CD4+ cell density and reduced expression of genes such as IL15. These effects may contribute to a compromised immune response against L. infantum in coinfected individuals, further impacting the structural organization of the spleen.
脾脏在内脏利什曼病的发病机制中起着关键作用。在疾病的严重形式中，脾脏会发生变化，从而影响其监测血液循环病原体的功能。在这项研究中，我们对 3 例复发内脏利什曼病患者的脾脏结构和基因表达改变进行了综合分析，其中 2 例合并感染了 HIV。我们的研究结果表明，IL6 信号通路在白髓紊乱中起重要作用，而 BCL10 和 ICOSLG 与脾脏组织有关。合并感染 HIV 和内脏利什曼病的患者脾脏 CD4+细胞密度较低，IL15 等基因的表达减少。这些影响可能导致合并感染个体对 L. infantum 的免疫反应受损，进一步影响脾脏的结构组织。
