University of Turin, Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center "Guido Tarone", Via Nizza 52, 10126 Turin, Italy.
University of Turin, Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center "Guido Tarone", Via Nizza 52, 10126 Turin, Italy.
Cell Rep. 2024 Jun 25;43(6):114273. doi: 10.1016/j.celrep.2024.114273. Epub 2024 Jun 5.
Phosphoinositides (PtdIns) are a family of differentially phosphorylated lipid second messengers localized to the cytoplasmic leaflet of both plasma and intracellular membranes. Kinases and phosphatases can selectively modify the PtdIns composition of different cellular compartments, leading to the recruitment of specific binding proteins, which control cellular homeostasis and proliferation. Thus, while PtdIns affect cell growth and survival during interphase, they are also emerging as key drivers in multiple temporally defined membrane remodeling events of mitosis, like cell rounding, spindle orientation, cytokinesis, and abscission. In this review, we summarize and discuss what is known about PtdIns function during mitosis and how alterations in the production and removal of PtdIns can interfere with proper cell division.
磷脂酰肌醇（PtdIns）是一组具有不同磷酸化的脂质第二信使，定位于质膜和细胞内膜的细胞质小叶。激酶和磷酸酶可以选择性地修饰不同细胞区室的 PtdIns 组成，导致特定结合蛋白的募集，从而控制细胞的内稳态和增殖。因此，虽然 PtdIns 在间期影响细胞的生长和存活，但它们也正在成为有丝分裂中多个时间定义的膜重塑事件的关键驱动因素，如细胞圆化、纺锤体定向、胞质分裂和分离。在这篇综述中，我们总结和讨论了 PtdIns 在有丝分裂中的功能以及 PtdIns 的产生和去除的改变如何干扰细胞的正常分裂。
