Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Anaerobe. 2024 Aug;88:102873. doi: 10.1016/j.anaerobe.2024.102873. Epub 2024 Jun 4.
C. difficile infection (CDI) is a costly and increasing burden on the healthcare systems of many developed countries due to the high rates of nosocomial infections. Despite the availability of several antibiotics with high response rates, effective treatment is hampered by recurrent infections. One potential mechanism for recurrence is the existence of C. difficile biofilms in the gut which persist through the course of antibiotics. In this review, we describe current developments in understanding the molecular mechanisms by which C. difficile biofilms form and are stabilized through extracellular biomolecular interactions.
艰难梭菌感染（CDI）是许多发达国家医疗体系的沉重负担，因为其院内感染率很高。尽管有几种抗生素具有很高的响应率，但由于反复感染，有效的治疗受到阻碍。复发的一个潜在机制是肠道中艰难梭菌生物膜的存在，这些生物膜在抗生素治疗过程中持续存在。在这篇综述中，我们描述了目前对艰难梭菌生物膜形成和通过细胞外生物分子相互作用稳定的分子机制的理解的最新进展。
