Makerere University, Kampala, Uganda
Makerere University, Kampala, Uganda.
BMJ Open. 2024 Jun 6;14(6):e079660. doi: 10.1136/bmjopen-2023-079660.
Primary dysmenorrhoea occurs in up to 50% of menstruating females. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used therapeutic remedies for dysmenorrhoea in Uganda. However, NSAIDs are associated with a 3-5 fold increase in the risk of gastrointestinal (GI) adverse drug effects.
We aimed to determine the prevalence and associated factors of self-reported NSAID-related GI adverse effects in female students who use NSAIDs in managing dysmenorrhoea-associated pain at Makerere University.
A cross-sectional study.
Makerere University's main campus, situated North of Kampala, Uganda.
314 female students pursuing an undergraduate programme at Makerere University and residing in different halls of residence and hostels.
Social demographic data, menstrual history and treatment data.
Overall, 314 valid responses were received from female students with a median age of 22 years (IQR: 18-29 years). The median age at menarche was 13 years (IQR: 9-18 years). 41% (n=129/314) of the respondents had used medication for dysmenorrhoea and 32% (n=41/129) of whom reported NSAID-associated GI adverse effects with nausea being the most frequently reported (44%, n=18/41)Factors independently associated with GI adverse effects were: age at menarche (p=0.026), duration of menstruation (p=0.030) and use of ibuprofen (p=0.005). Females taking ibuprofen for dysmenorrhoea were about four times as likely to have NSAID-associated GI adverse effects (adjusted OR 3.87, 95% CI 1.51 to 9.91) than those who did not receive ibuprofen. Logistic regression was used to determine factors associated with self-reported adverse effects of NSAIDs among the female students. A p<0.05 was considered statistically significant.
We found a considerably high prevalence of NSAID-related GI adverse effects driven by factors such as age at menarche and ibuprofen use.
原发性痛经发生在多达 50%的经期女性中。在乌干达，非甾体抗炎药（NSAIDs）是治疗痛经最常用的药物。然而，NSAIDs 会使胃肠道（GI）不良药物反应的风险增加 3-5 倍。
我们旨在确定在使用 NSAIDs 治疗痛经相关疼痛的 Makerere 大学女学生中，报告的 NSAID 相关 GI 不良事件的流行率和相关因素。
横断面研究。
乌干达坎帕拉北部的 Makerere 大学校园。
314 名攻读本科课程的女学生，分别居住在不同的宿舍和宿舍。
社会人口统计学数据、月经史和治疗数据。
总体而言，从女学生那里收到了 314 份有效回复，中位年龄为 22 岁（IQR：18-29 岁）。初潮年龄中位数为 13 岁（IQR：9-18 岁）。41%（n=129/314）的受访者曾使用药物治疗痛经，其中 32%（n=41/129）报告 NSAID 相关的 GI 不良事件，最常报告的是恶心（44%，n=18/41）。与 GI 不良事件相关的独立因素有：初潮年龄（p=0.026）、经期持续时间（p=0.030）和使用布洛芬（p=0.005）。因痛经而服用布洛芬的女性发生 NSAID 相关 GI 不良事件的可能性是未服用布洛芬的女性的近四倍（调整后的 OR 3.87，95%CI 1.51 至 9.91）。使用逻辑回归确定了女学生中 NSAID 相关不良反应的相关因素。p<0.05 被认为具有统计学意义。
我们发现，由于初潮年龄和布洛芬使用等因素，NSAID 相关的 GI 不良事件发生率相当高。
