产前暴露于硫酸镁与极低出生体重儿新生儿结局的关系：一项多中心研究。
Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study.
机构信息
Department of Neonatology, Centro Hospitalario Pereira Rossell, Universidad de la República, Montevideo, Uruguay.
Department of Obstetrics and Gynecology, Department of Statistics and Epidemiology. Hospital Puerto Montt, Facultad de Medicina Universidad Sebastián, Puerto Montt, Chile.
出版信息
J Perinatol. 2024 Nov;44(11):1663-1668. doi: 10.1038/s41372-024-02025-y. Epub 2024 Jun 7.
OBJECTIVE
To explore the association between antenatal magnesium sulfate (MgSO), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants.
STUDY DESIGN
Retrospective, cohort study of infants <32 weeks' GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities.
RESULTS
7418 VLBW infants were eligible. Antenatal MgSO was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49-0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50-0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72-1.71]). No differences between groups were observed in rates of morbidities.
CONCLUSION
Antenatal MgSO was associated with a decreased death rate after admission and in severe IVH/ death.
目的
探讨产前硫酸镁（MgSO）与极低出生体重（VLBW）儿死亡率和脑室内出血（IVH）发生率的关系。
研究设计
这是一项回顾性队列研究，纳入了 2015 年 1 月至 2020 年 12 月期间在 NEOCOSUR 网络中心出生、胎龄<32 周的婴儿。将受试者分为产前 MgSO 暴露组和非暴露组。主要结局为死亡、严重 IVH（III-IV 级）和严重 IVH/死亡的发生率。次要结局包括相关并发症。
结果
共有 7418 例 VLBW 婴儿符合条件。产前 MgSO 与入院后死亡率显著降低相关（调整后的优势比[aOR]0.67[95%置信区间[CI]，0.49-0.94]）和严重 IVH/死亡（aOR 0.68[95% CI，0.50-0.93]）。但严重 IVH 的发生率未见显著降低（aOR 1.11[95% CI，0.72-1.71]）。两组在并发症发生率方面无差异。
结论
产前 MgSO 与入院后死亡率降低和严重 IVH/死亡相关。
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