Moradi Yousef, Khateri Rozhin, Haghighi Ladan, Dehghani Shoaib, Hanis Shiva Mansouri, Valipour Mehrdad, Najmi Zahra, Fathollahy Zahra, Allahmoradi Meisam, Mansori Kamyar
Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Obstet Gynecol Sci. 2020 Jul;63(4):395-406. doi: 10.5468/ogs.19210. Epub 2020 Jun 24.
The aim of this systematic review and meta-analysis study was to determine the pooled estimate of the effect of antenatal magnesium sulfate (MgSO4) on intraventricular hemorrhage (IVH) in premature infants.
Two review authors independently searched all randomized clinical trials from international databases, including Medline (PubMed), Web of Sciences, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and Research Registers of ongoing trials (ClinicalTrials.gov), from January 1989 to August 2017. Two independent review authors were responsible for data collection. After extracting the necessary information from the evaluated articles, metaanalysis of the data was performed using Stata version 14. Also, sources of heterogeneity among studies were determined by Meta regression.
In this study, among 126 articles that were extracted from primary studies, 7 papers that evaluated the effect of MgSO4 on IVH were eligible for inclusion in the meta-analysis. The results of the meta-analysis showed that pooled relative risk (95% confidence interval [CI]) was 0.80 (95% CI, 0.63 to 1.03) for the effect of MgSO4 on IVH.
of this study showed that although MgSO4 had a protective effect on IVH in premature infants, this effect was not statistically significant. Further studies are needed to determine the best dosage, timing, and gestational age to achieve the optimum effect of MgSO4 on IVH.
International Prospective Register of Systematic Reviews (PROSPERO) Identifier: CRD42019119610.
本系统评价和荟萃分析研究的目的是确定产前硫酸镁（MgSO4）对早产儿脑室内出血（IVH）影响的合并效应估计值。
两名综述作者独立检索了1989年1月至2017年8月国际数据库中的所有随机临床试验，包括医学文献数据库（PubMed）、科学网、Scopus、Cochrane对照试验中心注册库（CENTRAL）和正在进行试验的研究注册库（ClinicalTrials.gov）。两名独立的综述作者负责数据收集。从评估的文章中提取必要信息后，使用Stata 14版对数据进行荟萃分析。此外，通过Meta回归确定研究之间异质性的来源。
在本研究中，从初步研究中提取的126篇文章中，有7篇评估了MgSO4对IVH影响的论文符合纳入荟萃分析的条件。荟萃分析结果显示，MgSO4对IVH影响的合并相对风险（95%置信区间[CI]）为0.80（95%CI，0.63至1.03）。
本研究结果表明，虽然MgSO4对早产儿IVH有保护作用，但这种作用在统计学上并不显著。需要进一步研究以确定最佳剂量、给药时间和胎龄，以实现MgSO4对IVH的最佳效果。
国际前瞻性系统评价注册库（PROSPERO）标识符：CRD42019119610。
