Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Department of Pharmacology, University of Oxford, Oxford, UK.
Amino Acids. 2024 Jun 6;56(1):39. doi: 10.1007/s00726-024-03398-2.
Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6-7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown.
血浆总半胱氨酸（tCys）与人体脂肪量密切相关。美司钠以剂量依赖性方式降低血浆 tCys，但尚不清楚其是否会干扰其他氨基酸或蛋白质的代谢。在这项 I 期研究中，我们发现，6-7 名个体单次接受 400、800、1200 或 1600mg 的美司钠治疗，仅轻微影响氨基酸谱，使血浆缬氨酸在各剂量水平升高。美司钠对 3-甲基组氨酸（一种蛋白质分解的标志物）没有影响。
