口服美司钠给药对完整氨基酸谱和 3-甲基组氨酸的急性影响：CYLOB 剂量发现研究的次要结果。
Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study.
机构信息
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Department of Pharmacology, University of Oxford, Oxford, UK.
出版信息
Amino Acids. 2024 Jun 6;56(1):39. doi: 10.1007/s00726-024-03398-2.
Abstract
Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6-7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown.
摘要
血浆总半胱氨酸（tCys）与人体脂肪量密切相关。美司钠以剂量依赖性方式降低血浆 tCys，但尚不清楚其是否会干扰其他氨基酸或蛋白质的代谢。在这项 I 期研究中，我们发现，6-7 名个体单次接受 400、800、1200 或 1600mg 的美司钠治疗，仅轻微影响氨基酸谱，使血浆缬氨酸在各剂量水平升高。美司钠对 3-甲基组氨酸（一种蛋白质分解的标志物）没有影响。
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本文引用的文献
1
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2
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Sci Rep. 2023 Nov 23;13(1):20609. doi: 10.1038/s41598-023-47676-7.
3
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Br J Nutr. 2024 Mar 14;131(5):786-800. doi: 10.1017/S0007114523002490. Epub 2023 Oct 27.
4
Determination of underivatized amino acids in human plasma using ion pair liquid chromatography/tandem mass spectrometry.
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5
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Adv Nutr. 2023 Sep;14(5):1211-1225. doi: 10.1016/j.advnut.2023.07.006. Epub 2023 Jul 30.
6
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7
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
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Front Aging. 2022 Aug 24;3:975129. doi: 10.3389/fragi.2022.975129. eCollection 2022.
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Obesity (Silver Spring). 2020 Jun;28(6):1075-1085. doi: 10.1002/oby.22763. Epub 2020 Apr 29.
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