School of Nursing, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, China.
Department of Nursing Science, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.
BMC Public Health. 2024 Jun 6;24(1):1518. doi: 10.1186/s12889-024-18932-w.
Primary osteoporosis (POP) is recognized as a "silent disease" and often ignored. This meta-analysis aimed to determine the prevalence of POP in the Chinese population over the past 20 years to raise awareness of the disease's epidemiology, which is hoped to help prevent and treat the condition better.
Eight English and three Chinese language databases were searched systematically from January 2002 to December 2023. Relevant data were analysed using Stata 16.0. Meta-regression and subgroup analyses were performed to explore causes of heterogeneity. A funnel plot was further drawn in combination with Egger and Begg tests to determine publication bias.
A total of 45 studies (241,813 participants) were included. The meta-analysis revealed that the overall prevalence of POP in the Chinese population was 18.2% (95% CI: 14.7-21.7%), showing a positive correlation with age. Specifically, prevalence rates were 23.4% (18.3-28.5%) in women and 11.5% (9.1-13.9%) in men. A notable increase was observed within the span of 20 years (16.9% before 2010 and 20.3% in 2011-2020). Notably, regional variations were observed, with southern China reporting a lower prevalence of 16.4% compared to 20.2% in northern China. Meta-regression suggested that sample size significantly influenced the estimation of point prevalence (P = 0.037).
Over the past two decades, there has been an increase in the prevalence of POP within the Chinese population. The growing prevalence of older individuals and women further highlights the urgency for tailored disease prevention and control measures.
原发性骨质疏松症（POP）被认为是一种“无声的疾病”，常常被忽视。本项荟萃分析旨在确定过去 20 年来中国人群中 POP 的患病率，以提高对该疾病流行病学的认识，希望有助于更好地预防和治疗这种疾病。
系统检索 2002 年 1 月至 2023 年 12 月期间的 8 个英文数据库和 3 个中文数据库，使用 Stata 16.0 分析相关数据。采用 Meta 回归和亚组分析来探讨异质性的原因。进一步结合 Egger 和 Begg 检验绘制漏斗图，以确定发表偏倚。
共纳入 45 项研究（241813 名参与者）。Meta 分析显示，中国人群 POP 的总体患病率为 18.2%（95%CI：14.7-21.7%），且与年龄呈正相关。具体而言，女性患病率为 23.4%（18.3-28.5%），男性为 11.5%（9.1-13.9%）。在 20 年内观察到显著增加（2010 年前为 16.9%，2011-2020 年为 20.3%）。值得注意的是，存在地域差异，南方地区的患病率为 16.4%，低于北方地区的 20.2%。Meta 回归提示，样本量对点患病率的估计有显著影响（P=0.037）。
在过去的 20 年中，中国人群中 POP 的患病率呈上升趋势。老年人口和女性的患病率不断增加，进一步凸显了制定有针对性的疾病预防和控制措施的紧迫性。
