Department of Urology, People's Hospital of Dayi County, Chengdu, 611300, China.
Department of Urology, Sichuan Clinical Reasearch Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China.
World J Surg Oncol. 2024 Jun 6;22(1):150. doi: 10.1186/s12957-024-03425-2.
To evaluate the predictors for short and long term urinary continence (UC) recovery after laparoscopic radical prostatectomy (LRP) from clinical and oncological variables.
We retrospectively collected data from 142 prostate cancer patients who underwent LRP between September 2014 and June 2021 at a tumor specialist diagnosis and treatment center in China. The rate of post-prostatectomy incontinence (PPI) was evaluated from immediate and at 3, 6 and 12 mo after LRP, and UC was defined as the use of no or one safety pad. Sixteen clinical and oncological variables were analyzed by univariate and multivariate regression analysis to determine whether they were associated with short (3 mo) or long term (12 mo) UC recovery after LRP.
After eliminating patients who were lost to follow-up, 129 patients were eventually included. The mean ± SD age was 68 ± 6.3 years. The UC rates of immediate, 3, 6 and 12 mo after the operation were 27.9%, 54.3%, 75.2% and 88.4%, respectively. Multivariate analyses revealed that membranous urethral length (MUL) was a protective predictor of UC after catheter extraction(P < 0.001), and at 3 mo (P < 0.001), 6 mo (P < 0.001) and 12 mo (P = 0.009) after surgery.
MUL is a significant independent factor that can contribute to short and long term UC recovery post-LRP, which may assist clinicians and their patients in counseling of treatment.
从临床和肿瘤学变量评估腹腔镜根治性前列腺切除术（LRP）后短期和长期尿控（UC）恢复的预测因素。
我们回顾性地收集了 2014 年 9 月至 2021 年 6 月在中国一家肿瘤专科诊疗中心接受 LRP 的 142 例前列腺癌患者的数据。从 LRP 后即刻以及 3、6 和 12 个月评估前列腺切除术后尿失禁（PPI）的发生率，并将 UC 定义为使用无或一个安全垫。通过单变量和多变量回归分析分析了 16 个临床和肿瘤学变量，以确定它们是否与 LRP 后短期（3 个月）或长期（12 个月）UC 恢复相关。
在消除随访丢失的患者后，最终纳入 129 例患者。患者的平均年龄为 68±6.3 岁。术后即刻、3、6 和 12 个月的 UC 率分别为 27.9%、54.3%、75.2%和 88.4%。多变量分析显示，膜部尿道长度（MUL）是拔管后 UC 的保护预测因素（P<0.001），并在术后 3 个月（P<0.001）、6 个月（P<0.001）和 12 个月（P=0.009）时。
MUL 是影响 LRP 后短期和长期 UC 恢复的重要独立因素，这可能有助于临床医生及其患者的治疗咨询。
