HIV 感染者中持续性 HPV 感染和宫颈病变的管理：一项回顾性观察性队列研究。
Management for persistent HPV infection and cervical lesions among women infected with HIV: a retrospective observational cohort study.
机构信息
Department of Clinical Laboratory, The Fourth People's Hospital of Nanning, Nanning, Guangxi, China.
Key Laboratory of Infectious Diseases, The Fourth People's Hospital of Nanning, Nanning, Guangxi, China.
出版信息
Virol J. 2024 Jun 6;21(1):133. doi: 10.1186/s12985-024-02405-y.
BACKGROUND
Early diagnosis and treatment of HPV persistent infection and cervical intraepithelial neoplasia, which have yet to be thoroughly characterized in Guangxi, Southwestern China, are the key preventative measures for the development of cervical cancer in women, particularly in HIV-infected women.
METHODS
A retrospective study of 181 patients with HPV infection or cervical intraepithelial neoplasia who received surgical excision of lesions and were prospectively enrolled at the Fourth People's Hospital of Nanning between January 2018 and February 2023 was performed. HPV-infected patients were divided into two subgroups: HIV-infected and HIV/HPV-coinfected patients and compare differences between these groups.
RESULTS
HPV16, 18, 52, and 58 were the most prevalent HPV genotypes. High-risk HPV was significantly co-infected with multiple genotypes (P = 0.0332). HIV-infected women were predisposed to HPV infection (P < 0.0001), and the development of cervical cancer at a young age (P = 0.0336) compared to HIV-uninfected women and the loop electrosurgical excision procedure (P = 0.0480) is preferred for the treatment.
CONCLUSIONS
HIV infection may increase HPV prevalence and lead to cervical cancer development at a young age. The loop electrosurgical excision procedure is an efficient evaluation and treatment strategy for HIV-infected women suffering from cervical intraepithelial neoplasia.
背景
在中国西南部的广西，尚未彻底明确 HPV 持续性感染和宫颈上皮内瘤变的情况，这是预防女性宫颈癌（尤其是 HIV 感染者）发展的关键措施。
方法
对 2018 年 1 月至 2023 年 2 月在南宁市第四人民医院接受手术切除病变的 181 例 HPV 感染或宫颈上皮内瘤变患者进行回顾性研究。将 HPV 感染患者分为 HIV 感染和 HIV/HPV 合并感染两组，并比较两组间的差异。
结果
HPV16、18、52 和 58 是最常见的 HPV 基因型。高危型 HPV 明显合并多种基因型感染（P=0.0332）。与 HIV 未感染女性相比，HIV 感染女性易发生 HPV 感染（P<0.0001），且更易发生年轻宫颈癌（P=0.0336）。与环形电切术（LEEP）相比，她们更倾向于采用 LEEP 治疗。
结论
HIV 感染可能增加 HPV 感染率，导致年轻宫颈癌的发生。LEEP 是针对患有宫颈上皮内瘤变的 HIV 感染女性的有效评估和治疗策略。
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