Hilgert I
Immunogenetics. 1985;21(2):153-9. doi: 10.1007/BF00364867.
The effect of an H-2IJ disparity on skin graft survival was studied in 18 mouse donor-recipient strain combinations, in which the recipients were treated with an efficient immunosuppressant, lentil lectin (LCA). The simultaneous I-J disparity essentially had no (or a slightly adverse) effect on the graft survival times in strain combinations differing at the K and I-A loci or in the entire H-2 complex. In two strain combinations incompatible at the D locus, the simultaneous I-J disparity promoted graft survival. The disparity at the I-J locus therefore seems to have only a marginal effect on the survival of allografts in most of the LCA-treated recipients, but it may promote graft survival in some animals. A similar tolerance-promoting effect was also observed with D disparity.
在18种小鼠供体-受体品系组合中研究了H-2IJ差异对皮肤移植存活的影响，其中受体用高效免疫抑制剂扁豆凝集素（LCA）进行处理。在K和I-A位点或整个H-2复合体存在差异的品系组合中，同时存在的I-J差异对移植存活时间基本没有（或有轻微不利）影响。在两个在D位点不相容的品系组合中，同时存在的I-J差异促进了移植存活。因此，在大多数经LCA处理的受体中，I-J位点的差异似乎对同种异体移植的存活只有很小的影响，但在某些动物中可能会促进移植存活。D差异也观察到了类似的促进耐受的效果。
