SARS-CoV-2 疫苗接种与女性医护人员的非自愿不孕不育无关：一项多中心队列研究。

SARS-CoV-2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study.

机构信息

Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St Gallen, Switzerland.

Division of Infectious Diseases, Cantonal Hospital Graubünden, Chur, Switzerland.

出版信息

Influenza Other Respir Viruses. 2024 Jun;18(6):e13333. doi: 10.1111/irv.13333.

DOI:10.1111/irv.13333

PMID:38845394

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11157148/

Abstract

BACKGROUND

There is debate about the causes of the recent birth rate decline in high-income countries worldwide. During the pandemic, concern about the effects on reproductive health has caused vaccine hesitancy. We investigated the association of SARS-CoV-2 vaccination and infection with involuntary childlessness.

METHODS

Females in fertility age within a prospective multicenter cohort of healthcare workers (HCW) were followed since August 2020. Data on baseline health, SARS-CoV-2-infection, and vaccination were obtained and regularly updated, in which serum samples were collected repetitively and screened for anti-nucleocapsid and anti-spike antibodies. In October 2023, participants indicated the presence of involuntary childlessness with onset during the pandemic, whereas those indicating an onset before the pandemic were excluded. The association of involuntary childlessness and SARS-CoV-2-vaccination and infection was investigated using univariable and multivariable analysis. Sensitivity analysis was performed to compare those reporting involuntary childlessness with those birthing a child since 2020.

RESULTS

Of 798 participants, 26 (3.2%) reported involuntary childlessness starting since the pandemic. Of the involuntary childless women, 73.1% (19/26) were vaccinated compared to 86.0% (664/772) without involuntary childlessness (p = 0.73). SARS-CoV-2 infection was reported by 76.9% (20/26) compared to 72.4% (559/772) of controls (p = 0.64). Neither SARS-CoV-2 vaccination (aOR 0.91 per dose, 95%CI 0.67-1.26) nor infection (aOR per infection 1.05, 95%CI 0.62-1.71) was associated with involuntary childlessness. Sensitivity analysis confirmed these results.

CONCLUSIONS

Among female HCW of fertility age, 3.2% indicated involuntary childlessness, which is comparable to pre-pandemic data. No association between involuntary childlessness and SARS-CoV-2 vaccination or infection was found.

摘要

背景

全球高收入国家的出生率下降原因存在争议。在大流行期间，人们对其对生殖健康的影响感到担忧，从而导致了对疫苗的犹豫。我们调查了 SARS-CoV-2 疫苗接种和感染与非意愿性不孕之间的关联。

方法

在一个前瞻性的医疗保健工作者（HCW）多中心队列中，对处于生育年龄的女性进行了随访。自 2020 年 8 月以来，收集了基线健康、SARS-CoV-2 感染和疫苗接种的数据，并定期进行更新，其中重复采集血清样本并进行核衣壳和刺突抗体检测。2023 年 10 月，参与者报告了大流行期间开始出现的非意愿性不孕，而那些报告发病时间早于大流行的参与者则被排除在外。使用单变量和多变量分析调查了非意愿性不孕与 SARS-CoV-2 疫苗接种和感染之间的关联。进行了敏感性分析，以比较报告非意愿性不孕的参与者和自 2020 年以来生育孩子的参与者。

结果

在 798 名参与者中，有 26 名（3.2%）报告自大流行以来开始出现非意愿性不孕。在非意愿性不孕的女性中，有 73.1%（19/26）接种了疫苗，而没有非意愿性不孕的女性为 86.0%（664/772）（p=0.73）。有 76.9%（20/26）的人报告感染了 SARS-CoV-2，而对照组为 72.4%（559/772）（p=0.64）。SARS-CoV-2 疫苗接种（每剂剂量的 OR 0.91，95%CI 0.67-1.26）或感染（每感染的 OR 1.05，95%CI 0.62-1.71）均与非意愿性不孕无关。敏感性分析证实了这些结果。