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心脏结节病与巨细胞性心肌炎的临床与组织学交叉点

The Clinical and Histological Intersection of Cardiac Sarcoidosis and Giant Cell Myocarditis.

作者信息

Sharma Toishi, Wahlberg Kramer, Keating Friederike, Harhash Ahmed, Cooper Leslie T

机构信息

Cardiology, University of Vermont, Burlington, USA.

Internal Medicine, Mayo Clinic, Jacksonville, USA.

出版信息

Cureus. 2024 May 7;16(5):e59783. doi: 10.7759/cureus.59783. eCollection 2024 May.

DOI:10.7759/cureus.59783
PMID:38846240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11154654/
Abstract

The clinical and imaging features of cardiac sarcoidosis (CS) and giant cell myocarditis (GCM) are occasionally indistinguishable. This is a case of heart block and ventricular tachycardia where cardiac MRI, fluorodeoxyglucose positron emission tomography (FDG-PET) and biopsy revealed intermediate clinicohistologic phenotype between CS and GCM. This highlights gaps in the management of overlap conditions.

摘要

心脏结节病（CS）和巨细胞性心肌炎（GCM）的临床及影像学特征有时难以区分。本文报告一例心脏传导阻滞和室性心动过速患者，心脏磁共振成像（MRI）、氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）及活检显示其临床组织学表型介于CS和GCM之间。这凸显了重叠病症管理方面的差距。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1333/11154654/381f8e5575d5/cureus-0016-00000059783-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1333/11154654/4b81f05e0c00/cureus-0016-00000059783-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1333/11154654/f93abacbcf69/cureus-0016-00000059783-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1333/11154654/849bc53f52e8/cureus-0016-00000059783-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1333/11154654/381f8e5575d5/cureus-0016-00000059783-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1333/11154654/4b81f05e0c00/cureus-0016-00000059783-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1333/11154654/f93abacbcf69/cureus-0016-00000059783-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1333/11154654/849bc53f52e8/cureus-0016-00000059783-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1333/11154654/381f8e5575d5/cureus-0016-00000059783-i04.jpg

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本文引用的文献

1
Cardiac magnetic resonance in giant cell myocarditis: a matched comparison with cardiac sarcoidosis.巨细胞心肌炎的心脏磁共振：与心脏结节病的匹配比较。
Eur Heart J Cardiovasc Imaging. 2023 Mar 21;24(4):404-412. doi: 10.1093/ehjci/jeac265.
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Sarcoidosis-Related Cardiomyopathy: Current Knowledge, Challenges, and Future Perspectives State-of-the-Art Review.结节病相关性心肌病：现状、挑战与未来展望——综述
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RNA-Sequencing Reveals a Distinct Transcriptomic Signature for Giant Cell Myocarditis and Identifies Novel Druggable Targets.
RNA测序揭示了巨细胞性心肌炎独特的转录组特征并鉴定出新型可成药靶点。
Circ Res. 2021 Jul 23;129(3):451-453. doi: 10.1161/CIRCRESAHA.121.319317. Epub 2021 Jun 14.
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J Am Heart Assoc. 2021 Mar 16;10(6):e019415. doi: 10.1161/JAHA.120.019415. Epub 2021 Mar 4.
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A clinical and histopathologic comparison of cardiac sarcoidosis and idiopathic giant cell myocarditis.心脏结节病与特发性巨细胞心肌炎的临床及组织病理学比较
J Am Coll Cardiol. 2003 Jan 15;41(2):322-9. doi: 10.1016/s0735-1097(02)02715-8.
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