Chen Xingxing, Fu Liying, Zhu Zhongxin, Wang Yunchao
Clinical Research Center, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.
Voluntary Blood Donation Service Center of Xiaoshan District, Hangzhou, Zhejiang, China.
Front Nutr. 2024 May 23;11:1367174. doi: 10.3389/fnut.2024.1367174. eCollection 2024.
The connection between magnesium and hepatic steatosis has not been well-studied. This study aimed to explore the link between magnesium intake and hepatic steatosis, utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020.
The analysis included 5,935 participants, excluding individuals with hepatitis infection or substantial alcohol consumption. Magnesium intake assessment was based on 24-h dietary recalls. Hepatic steatosis evaluation employed the controlled attenuation parameter (CAP), measured via transient elastography. Multivariate regression and subgroup analyses were conducted to scrutinize the relationship between magnesium intake and CAP values.
A higher magnesium intake was associated with lower CAP values, after adjusting for potential confounders. Subgroup analyses indicated an inverted U-shaped correlation between magnesium intake and CAP in women, White people, and non-hypertensive individuals, with respective inflection points at 126, 124.5, and 125 mg/day, respectively. Below these thresholds, a higher magnesium intake correlated with increased CAP values, while above these points, it was associated with decreased CAP.
This extensive population-based study indicates an inverse relationship between magnesium intake and hepatic steatosis in Americans. This relationship displays an inverted U-curve, varying before and after specified inflection points in women, White people, and non-hypertensive individuals. These findings offer insights into tailored magnesium supplementation strategies for preventing and treating liver steatosis, based on gender and ethnicity.
镁与肝脂肪变性之间的联系尚未得到充分研究。本研究旨在利用2017 - 2020年美国国家健康与营养检查调查（NHANES）的数据，探讨镁摄入量与肝脂肪变性之间的联系。
分析纳入5935名参与者，排除肝炎感染或大量饮酒者。镁摄入量评估基于24小时饮食回忆。肝脂肪变性评估采用通过瞬时弹性成像测量的受控衰减参数（CAP）。进行多变量回归和亚组分析以审查镁摄入量与CAP值之间的关系。
在调整潜在混杂因素后，较高的镁摄入量与较低的CAP值相关。亚组分析表明，女性、白人和非高血压个体的镁摄入量与CAP之间呈倒U形相关性，各自的拐点分别为每天126毫克、124.5毫克和125毫克。低于这些阈值时，较高的镁摄入量与CAP值增加相关，而高于这些点时，则与CAP值降低相关。
这项基于广泛人群的研究表明，美国人的镁摄入量与肝脂肪变性之间存在负相关关系。这种关系呈现倒U曲线，在女性、白人和非高血压个体的特定拐点前后有所不同。这些发现为基于性别和种族制定预防和治疗肝脂肪变性的镁补充策略提供了见解。
