Wu Wenlong, Gong Ming, Liu Pan, Yu Huiying, Gao Xue, Zhao Xin
Department of Cardiology, the Second Hospital of Dalian Medical University, No.467, Zhongshan Road, Shaku District, Dalian, 116023, China.
Department of Cardiology, Liao Ning University of Traditional Chinese Medicine, No.79, Chong Shan East Road, Huanggu District, Shenyang, 110085, China.
Diabetol Metab Syndr. 2025 Jun 16;17(1):217. doi: 10.1186/s13098-025-01772-y.
This article provides a comprehensive and in-depth exploration of the multifaceted effects of Hypomagnesemia on human health, with a specific focus on its intricate associations with mechanisms regulating blood pressure and metabolic syndrome. Firstly, the fundamental concept of hypomagnesemia is elucidated, followed by a detailed analysis of its prevalence, risk factors, and Magnesium Deficiency Score. Furthermore, this article delves into the intricate relationship between hypomagnesemia and blood pressure regulation, encompassing its impact on endothelial function, vascular calcification, oxidative stress and inflammatory response, sympathetic nervous system activity as well as the renin-angiotensin-aldosterone system (RAAS). Additionally, it explores the correlation between hypomagnesemia and insulin resistance, metabolic syndrome along with other health issues. Notably noteworthy is that this paper also places special emphasis on exploring the potential role of hypomagnesemia in specific diseases such as renal hypertension and preeclampsia while providing novel insights for their prevention and treatment. Finally, this article summarizes the diverse effects of hypomagnesemia on health while anticipating future research directions. Future studies should further investigate the pathogenesis underlying hypomagnesemia while optimizing assessment methods for magnesium deficiency to develop targeted intervention strategies aimed at offering improved treatment options alongside preventive measures for patients.
本文全面深入地探讨了低镁血症对人体健康的多方面影响，特别关注其与血压调节和代谢综合征调控机制的复杂关联。首先，阐述了低镁血症的基本概念，接着详细分析了其患病率、风险因素和镁缺乏评分。此外，本文深入研究了低镁血症与血压调节之间的复杂关系，包括其对内皮功能、血管钙化、氧化应激和炎症反应、交感神经系统活动以及肾素 - 血管紧张素 - 醛固酮系统（RAAS）的影响。此外，还探讨了低镁血症与胰岛素抵抗、代谢综合征以及其他健康问题之间的相关性。值得注意的是，本文还特别强调探索低镁血症在诸如肾性高血压和先兆子痫等特定疾病中的潜在作用，同时为其预防和治疗提供新的见解。最后，本文总结了低镁血症对健康的多种影响，同时展望了未来的研究方向。未来的研究应进一步探究低镁血症的发病机制，优化镁缺乏的评估方法，以制定有针对性的干预策略，为患者提供更好的治疗选择和预防措施。
