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一例胆管炎和内镜逆行胰胆管造影术后胆汁瘤的罕见病例

A Rare Case of Biloma after Ascending Cholangitis and Endoscopic Retrograde Cholangiopancreatography.

作者信息

Hernandez Perez Laura, Chandra Aishwarya, Ali Ruhma, Sharma Hari, Miller Richard, Hussain Muhammad

机构信息

Department of Internal Medicine, New York Medical College at St. Michael's Medical Center, Newark, USA.

Department of Pulmonology and Critical Care, New York Medical College at St. Michael's Medical Center, Newark, USA.

出版信息

Eur J Case Rep Intern Med. 2024 May 2;11(6):004482. doi: 10.12890/2024_004482. eCollection 2024.

Abstract

INTRODUCTION

Biloma is an uncommon form of liver abscess composed of bile usually associated with procedures of the biliary tree and gallbladder. Cholangitis can be acute or chronic, can result in partial or complete obstruction of the flow of bile. The infection of the bile is so common, that positive blood cultures are highly characteristic. In the case of a suppurative cholangitis with signs of sepsis treatment alone with antibiotics is usually not sufficient to achieve medical remission. Multiple hepatic abscesses are often present, and the mortality approaches 100% unless prompt endoscopic or surgical relief of the obstruction and drainage of infected bile are carried out. Endoscopic retrograde cholangiopancreatography ERCP with endoscopic sphincterotomy is the preferred initial procedure for both establishing a definitive diagnosis and providing effective therapy.

CASE DESCRIPTION

We present the case of a 69-year-old female patient with complex chronic comorbidities who presented with acute cholangitis initially managed with endoscopically inserted stent and later complicated by sepsis and biloma formation. The bile was drained, and it showed an infection with spp. requiring antifungal therapy.

CONCLUSIONS

The failure to perform sphincterotomy in patients with suppurative cholangitis can contribute to the backflow of bile and worse outcomes.

LEARNING POINTS

Biloma formation is a rare complication of biliary duct procedures and diseases such as cholangitis. A prompt identification of signs of complications in patients with disease of the biliary ducts is key in preventing clinical deterioration.Sphincterotomy is vital in the management of ascending cholangitis, as it prevents backflow of bile into the intrahepatic biliary system.The presence of multiple comorbidities in complex cases can become an obstacle to optimal management and drainage of septic bile.

摘要

引言

胆汁瘤是肝脓肿的一种罕见形式,由胆汁构成,通常与胆管树和胆囊的手术相关。胆管炎可分为急性或慢性,可导致胆汁流动部分或完全受阻。胆汁感染很常见,血培养阳性具有高度特征性。在伴有败血症体征的化脓性胆管炎病例中,仅用抗生素治疗通常不足以实现病情缓解。常出现多发性肝脓肿,除非及时进行内镜或手术解除梗阻并引流感染胆汁,否则死亡率接近100%。内镜逆行胰胆管造影(ERCP)联合内镜括约肌切开术是确立明确诊断和提供有效治疗的首选初始方法。

病例描述

我们报告一例69岁患有复杂慢性合并症的女性患者,最初表现为急性胆管炎,最初通过内镜置入支架进行治疗,后来并发败血症和胆汁瘤形成。胆汁被引流出来,显示感染了 菌属,需要抗真菌治疗。

结论

化脓性胆管炎患者未进行括约肌切开术可能导致胆汁逆流和更差的预后。

学习要点

胆汁瘤形成是胆管手术和胆管炎等疾病的罕见并发症。及时识别胆管疾病患者的并发症迹象是预防临床病情恶化的关键。括约肌切开术在治疗上行性胆管炎中至关重要,因为它可防止胆汁逆流至肝内胆管系统。复杂病例中存在多种合并症可能成为最佳处理和引流感染胆汁的障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f2/11152226/1271a06e9a2b/4482_Fig1.jpg

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