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大鼠隔旁核中两种不同的神经元群体对参与刺激驱动的奖励寻求行为的编码作用相反。

Two Distinct Neuronal Populations in the Rat Parafascicular Nucleus Oppositely Encode the Engagement in Stimulus-driven Reward-seeking.

机构信息

Aix-Marseille Université, CNRS, Laboratoire de Neurosciences Cognitives, UMR 7291, Marseille, France.

Institut de Neurosciences de la Timone, Aix-Marseille Univ, CNRS, INT, Marseille, France.

出版信息

Curr Neuropharmacol. 2024;22(9):1551-1565. doi: 10.2174/1570159X22666240131114225.

DOI:10.2174/1570159X22666240131114225
PMID:38847144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11097993/
Abstract

BACKGROUND

The thalamus is a phylogenetically well-preserved structure. Known to densely contact cortical regions, its role in the transmission of sensory information to the striatal complex has been widely reconsidered in recent years.

METHODS

The parafascicular nucleus of the thalamus (Pf) has been implicated in the orientation of attention toward salient sensory stimuli. In a stimulus-driven reward-seeking task, we sought to characterize the electrophysiological activity of Pf neurons in rats.

RESULTS

We observed a predominance of excitatory over inhibitory responses for all events in the task. Neurons responded more strongly to the stimulus compared to lever-pressing and reward collecting, confirming the strong involvement of the Pf in sensory information processing. The use of long sessions allowed us to compare neuronal responses to stimuli between trials when animals were engaged in action and those when they were not. We distinguished two populations of neurons with opposite responses: MOTIV+ neurons responded more intensely to stimuli followed by a behavioral response than those that were not. Conversely, MOTIV- neurons responded more strongly when the animal did not respond to the stimulus. In addition, the latency of excitation of MOTIV- neurons was shorter than that of MOTIV+ neurons.

CONCLUSION

Through this encoding, the Pf could perform an early selection of environmental stimuli transmitted to the striatum according to motivational level.

摘要

背景

丘脑是一个在进化上保存完好的结构。已知其与皮质区域密集接触，近年来，其在将感觉信息传递到纹状体复合体中的作用受到了广泛的重新考虑。

方法

丘脑束旁核（Pf）被认为参与了对显著感觉刺激的注意力定向。在一个受刺激驱动的寻求奖励任务中，我们试图描述大鼠 Pf 神经元的电生理活动。

结果

我们观察到，在任务的所有事件中，兴奋性反应都超过了抑制性反应。与按压杠杆和收集奖励相比，神经元对刺激的反应更强烈，这证实了 Pf 在感觉信息处理中的强烈参与。使用长时间的实验，我们能够比较动物在执行动作时和不执行动作时对刺激的神经元反应。我们区分了两种具有相反反应的神经元群体：MOTIV+神经元对随后的行为反应的刺激反应比那些没有反应的刺激反应更强烈。相反，当动物对刺激没有反应时，MOTIV-神经元的反应更强烈。此外，MOTIV-神经元的兴奋潜伏期比 MOTIV+神经元短。

结论

通过这种编码，Pf 可以根据动机水平对传递到纹状体的环境刺激进行早期选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/fdc0749dbfb4/CN-22-1551_F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/cb00bf6748f8/CN-22-1551_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/7227e4177d1e/CN-22-1551_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/f2bd11e57d8b/CN-22-1551_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/db97c824b8b4/CN-22-1551_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/2cd36dffa96c/CN-22-1551_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/dbe563e57af4/CN-22-1551_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/d3bd5965cd07/CN-22-1551_F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/fdc0749dbfb4/CN-22-1551_F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/cb00bf6748f8/CN-22-1551_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/7227e4177d1e/CN-22-1551_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/f2bd11e57d8b/CN-22-1551_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/db97c824b8b4/CN-22-1551_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/2cd36dffa96c/CN-22-1551_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/dbe563e57af4/CN-22-1551_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/d3bd5965cd07/CN-22-1551_F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e41a/11097993/fdc0749dbfb4/CN-22-1551_F8.jpg

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