Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, 04510 Ciudad de México, CDMX, Mexico.
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, 04510 Ciudad de México, CDMX, Mexico.
Neuron. 2018 Nov 7;100(3):739-752.e5. doi: 10.1016/j.neuron.2018.09.052. Epub 2018 Oct 18.
One of the main inputs driving striatal activity is the thalamostriatal projection. While the hypothesis postulating that the different thalamostriatal projections contribute differentially to shape the functions of the striatum is largely accepted, existing technical limitations have hampered efforts to prove it. Here, through the use of electrophysiological recordings of antidromically photo-identified thalamostriatal neurons and the optogenetic inhibition of thalamostriatal terminals, we identify that the thalamostriatal projections from the parafascicular and the ventroposterior regions of the thalamus contribute to the smooth initiation and the appropriate execution of a sequence of movements. Our results support a model in which both thalamostriatal projections have specific contributions to the initiation and execution of sequences, highlighting the specific contribution of the ventroposterior thalamostriatal connection for the repetition of actions.
驱动纹状体活动的主要输入之一是丘脑纹状体投射。虽然假设不同的丘脑纹状体投射对塑造纹状体的功能有不同的贡献已被广泛接受，但现有的技术限制阻碍了证明这一假说的努力。在这里，我们通过使用逆行光鉴定的丘脑纹状体神经元的电生理记录和丘脑纹状体末梢的光遗传学抑制，确定来自丘脑旁正中区和腹后外侧区的丘脑纹状体投射有助于平滑启动和适当执行一系列运动。我们的结果支持这样一种模型，即两条丘脑纹状体投射都对运动序列的发起和执行有特定的贡献，突出了腹后外侧丘脑纹状体连接在动作重复中的特定贡献。
