Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, P. R. China.
Shanxi-Zheda Institute of advanced Materials and Chemical Engineering, Taiyuan, 030032, P. R. China.
Adv Healthc Mater. 2024 Nov;13(28):e2400930. doi: 10.1002/adhm.202400930. Epub 2024 Jul 4.
Electrohydrodynamic (EHD) direct-writing has recently gained attention as a highly promising additive manufacturing strategy for fabricating intricate micro/nanoscale architectures. This technique is particularly well-suited for mimicking the extracellular matrix (ECM) present in biological tissue, which serves a vital function in facilitating cell colonization, migration, and growth. The integration of EHD direct-writing with other techniques has been employed to enhance the biological performance of scaffolds, and significant advancements have been made in the development of tailored scaffold architectures and constituents to meet the specific requirements of various biomedical applications. Here, a comprehensive overview of EHD direct-writing is provided, including its underlying principles, demonstrated materials systems, and biomedical applications. A brief chronology of EHD direct-writing is provided, along with an examination of the observed phenomena that occur during the printing process. The impact of biomaterial selection and architectural topographic cues on biological performance is also highlighted. Finally, the major limitations associated with EHD direct-writing are discussed.
静电纺丝（EHD）直接书写最近作为一种很有前途的增材制造策略引起了人们的关注，可用于制造复杂的微/纳尺度结构。该技术特别适合模拟生物组织中存在的细胞外基质（ECM），它在促进细胞定植、迁移和生长方面起着至关重要的作用。EHD 直接书写与其他技术的结合已被用于增强支架的生物性能，并且在开发定制支架结构和组成部分以满足各种生物医学应用的特定要求方面取得了重大进展。在这里，提供了对 EHD 直接书写的全面概述，包括其基本原理、已证明的材料系统和生物医学应用。简要介绍了 EHD 直接书写的发展历程，并考察了在打印过程中发生的观察到的现象。还强调了生物材料选择和建筑形貌线索对生物性能的影响。最后，讨论了与 EHD 直接书写相关的主要限制。
