School of Nursing, Peking University, Beijing, People's Republic of China.
The Second College of Clinical Medicine, Wenzhou Medical University, Wenzhou, People's Republic of China.
Contemp Nurse. 2024 Oct;60(5):479-495. doi: 10.1080/10376178.2024.2360960. Epub 2024 Jun 7.
Growing evidence shows that metabolic syndrome and frailty are significantly associated. Screening and assessing frailty in patients with metabolic syndrome is important to help improve their clinical outcomes and quality of life. Therefore, understanding the prevalence of frailty in patients with metabolic syndrome is the first critical step, however, the prevalence reported in the literature varies widely.
To pool the overall prevalence of frailty among patients with metabolic syndrome.
Systematic review and meta-analysis.
The Cochrane Library, PubMed, Web of Science, Embase, APA PsycINFO, Scopus, CINAHL Complete, CNKI, Wan Fang, SinoMed, and VIP databases were searched from the inception to March 6, 2024. Statistical analysis was performed using STATA15 software. The prevalence was pooled using the random-effects model. The sources of heterogeneity were investigated by using meta-regression and subgroup analyses.
A total of 22 original studies published between 2007 and 2023 were included in this systematic review and meta-analysis, involving 19,921 metabolic syndrome patients. The prevalence of frailty and pre-frailty among patients with metabolic syndrome was 20% (95% : 16% to 25%, = 99.44%) and 45% (95% : 36% to 53%, = 99.20%). Subgroup analyses revealed differences in prevalence by frailty instruments, geographic regions, study settings, publication years, study quality, study design, and different components of metabolic syndrome.
This systematic review and meta-analysis showed the high prevalence of frailty and pre-frailty in patients with metabolic syndrome In the future, more high-quality longitudinal studies and exploration of other potential demographic characteristics that may influence frailty are needed to understand more information on frailty in patients with metabolic syndrome.
越来越多的证据表明，代谢综合征和衰弱显著相关。对代谢综合征患者进行衰弱筛查和评估，有助于改善其临床结局和生活质量。因此，了解代谢综合征患者衰弱的患病率是至关重要的第一步，但文献中报告的患病率差异很大。
汇总代谢综合征患者衰弱的总体患病率。
系统评价和荟萃分析。
检索 Cochrane 图书馆、PubMed、Web of Science、Embase、APA PsycINFO、Scopus、CINAHL Complete、CNKI、万方、中国生物医学文献服务系统和维普数据库，检索时间截至 2024 年 3 月 6 日。使用 STATA15 软件进行统计分析。采用随机效应模型汇总患病率。采用亚组分析和 Meta 回归分析探讨异质性来源。
本系统评价和荟萃分析共纳入 2007 年至 2023 年期间发表的 22 项原始研究，涉及 19921 例代谢综合征患者。代谢综合征患者衰弱和衰弱前期的患病率分别为 20%（95%CI：16%25%， = 99.44%）和 45%（95%CI：36%53%， = 99.20%）。亚组分析显示，衰弱工具、地理位置、研究场所、发表年份、研究质量、研究设计以及代谢综合征的不同成分等因素的差异与患病率有关。
本系统评价和荟萃分析显示，代谢综合征患者衰弱和衰弱前期的患病率较高。未来需要更多高质量的纵向研究，并探索可能影响衰弱的其他潜在人口统计学特征，以了解更多关于代谢综合征患者衰弱的信息。
