Jordan N S, Schauer P K, Schauer A, Nightingale C, Golub G, Martin R S, Williams H M
J Clin Oncol. 1985 Apr;3(4):559-61. doi: 10.1200/JCO.1985.3.4.559.
In an attempt to determine the influence of administration time on cisplatin-induced emesis, 20 adults previously untreated with cisplatin were enrolled into this double-blind study. Twenty patients were randomly assigned to receive high-dose cisplatin (greater than 100 mg/m2) either by a one-hour infusion or by an eight-hour infusion. All patients received antiemetic therapy with metoclopramide 2 mg/kg intravenously one-half hour before cisplatin administration, and 1 1/2, 3 1/2, 5 1/2, and 8 1/2 hours after cisplatin administration. Patients in the eight-hour infusion group experienced significantly fewer emesis episodes than did patients in the one-hour infusion group. The median of emesis episodes in the eight-hour group was one (range, 0 to 2) and in the one-hour group was three (range, 0 to 8). In patients receiving high-dose cisplatin plus metoclopramide, increasing the administration time from one hour to eight hours resulted in a small but significant decrease in emesis episodes. The cisplatin infusion rate should be considered as a variable in cisplatin-antiemetic trials.
为了确定给药时间对顺铂所致呕吐的影响，20名既往未接受过顺铂治疗的成年人被纳入这项双盲研究。20名患者被随机分配，分别接受1小时输注或8小时输注的大剂量顺铂（大于100mg/m²）。所有患者在顺铂给药前半小时静脉注射2mg/kg甲氧氯普胺进行止吐治疗，并在顺铂给药后1.5、3.5、5.5和8.5小时再次给药。8小时输注组的患者呕吐发作次数明显少于1小时输注组的患者。8小时组呕吐发作次数的中位数为1次（范围为0至2次），1小时组为3次（范围为0至8次）。在接受大剂量顺铂加甲氧氯普胺治疗的患者中，给药时间从1小时增加到8小时导致呕吐发作次数有小幅但显著的减少。在顺铂-止吐试验中，应将顺铂输注速率视为一个变量。
