CDH1 基因多态性与胃癌风险的关联：基于 44 项研究的荟萃分析。

Associations between CDH1 gene polymorphisms and the risk of gastric cancer: A meta-analysis based on 44 studies.

机构信息

Department of Gastroenterology, Weifang People's Hospital, The First Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.

School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.

出版信息

Medicine (Baltimore). 2024 Jun 7;103(23):e38244. doi: 10.1097/MD.0000000000038244.

DOI:10.1097/MD.0000000000038244

PMID:38847676

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11155553/

Abstract

BACKGROUND

Numerous studies have investigated the association between CDH1 polymorphisms and gastric cancer (GC) risk. However, the results have been inconsistent and controversial. To further determine whether CDH1 polymorphisms increase the risk of GC, we conducted a meta-analysis by pooling the data.

METHODS

Relevant case-control studies were collected from PubMed, Embase, Web of Science and Cochrane databases up to January 7, 2024. Subsequently, odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of correlations. A sensitivity analysis was performed to evaluate the robustness and reliability of these included studies.

RESULTS

A total of 25 articles including 44 studies, were included in this meta-analysis, including 26 studies on rs16260, 6 studies on rs3743674, 7 studies on rs5030625, and 5 studies on rs1801552. The pooled results showed that rs16260 was remarkably associated with an increased GC risk of GC among Caucasians. Moreover, the rs5030625 variation dramatically enhanced GC predisposition in the Asian population. However, no evident correlations between CDH1 rs3743674 and rs1801552 polymorphisms and GC risk were observed.

CONCLUSIONS

Our findings suggested that CDH1 gene polymorphisms were significantly correlated with GC risk, especially in rs16260 and rs5030625 polymorphisms.

摘要

背景

许多研究调查了 CDH1 多态性与胃癌（GC）风险之间的关联。然而，结果不一致且存在争议。为了进一步确定 CDH1 多态性是否会增加 GC 的风险，我们进行了荟萃分析以汇总数据。

方法

从 PubMed、Embase、Web of Science 和 Cochrane 数据库中收集截至 2024 年 1 月 7 日的相关病例对照研究。随后，使用比值比（ORs）及其 95%置信区间（CIs）来评估相关性的强度。进行敏感性分析以评估这些纳入研究的稳健性和可靠性。

结果

这项荟萃分析共纳入了 25 篇文章，包含 44 项研究，其中包括 26 项关于 rs16260 的研究、6 项关于 rs3743674 的研究、7 项关于 rs5030625 的研究和 5 项关于 rs1801552 的研究。汇总结果表明，rs16260 与高加索人群的 GC 风险显著相关。此外，rs5030625 变异显著增加了亚洲人群的 GC 易感性。然而，CDH1 rs3743674 和 rs1801552 多态性与 GC 风险之间没有明显的相关性。