白细胞介素 6、8 和 10 基因多态性在胃癌中的作用：荟萃分析。
The roles of IL-6, IL-8 and IL-10 gene polymorphisms in gastric cancer: A meta-analysis.
机构信息
Department of Clinical Laboratory, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang, China.
Department of General Surgery, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang, China.
出版信息
Cytokine. 2018 Nov;111:230-236. doi: 10.1016/j.cyto.2018.08.024. Epub 2018 Sep 6.
BACKGROUND
Recently, the roles of interleukin-6 (IL-6), IL-8 and IL-10 gene polymorphisms in gastric cancer have been extensively studied, with conflicting results. Therefore, we conducted the present study to better assess the potential correlations between these interleukin gene polymorphisms and gastric cancer.
METHODS
Eligible articles were searched in PubMed, Medline, Embase, Web of Science and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between interleukin gene polymorphisms and the risk of gastric cancer.
RESULTS
A total of 73 case-control studies were finally included. Significant associations with the risk of gastric cancer were only detected for the IL-8 rs4073 polymorphism in overall analyses. Further subgroup analyses according to ethnicity of participants revealed that the IL-6 rs1800796, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 polymorphisms were all significantly associated with the risk of gastric cancer in Asians. No positive results were found for any investigated interleukin gene polymorphisms in Caucasians.
CONCLUSIONS
Our findings suggest that IL-6 rs1800796, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 polymorphisms may serve as genetic biomarkers of gastric cancer in Asians.
背景
最近，白细胞介素 6（IL-6）、IL-8 和 IL-10 基因多态性在胃癌中的作用得到了广泛研究，但结果存在争议。因此，我们进行了本研究，以更好地评估这些白细胞介素基因多态性与胃癌之间的潜在相关性。
方法
在 PubMed、Medline、Embase、Web of Science 和中国知网（CNKI）中搜索符合条件的文献。使用比值比（ORs）和 95%置信区间（CIs）来检测白细胞介素基因多态性与胃癌风险之间的任何潜在关联。
结果
最终共纳入 73 项病例对照研究。总体分析仅发现白细胞介素 8 rs4073 多态性与胃癌风险存在显著相关性。根据参与者的种族进行进一步的亚组分析表明，IL-6 rs1800796、IL-8 rs4073、IL-10 rs1800871、IL-10 rs1800872 和 IL-10 rs1800896 多态性在亚洲人群中均与胃癌风险显著相关。在高加索人群中未发现任何白细胞介素基因多态性与胃癌风险相关的阳性结果。
结论
我们的研究结果表明，IL-6 rs1800796、IL-8 rs4073、IL-10 rs1800871、IL-10 rs1800872 和 IL-10 rs1800896 多态性可能是亚洲人群胃癌的遗传生物标志物。
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