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二陈汤辅助治疗肥胖症疗效的Meta 分析：系统评价和Meta 分析研究方案。

Meta-analysis of the efficacy of Er Chen Tang in the adjuvant treatment of obesity: A study protocol for systematic review and meta-analysis.

机构信息

The First Clinical Medical College of Heilongjiang University of Chinese Medicine, Haerbin, Heilongjiang Province, China.

The Second Clinical Medical College of Heilongjiang University of Chinese Medicine, Haerbin, Heilongjiang Province, China.

出版信息

Medicine (Baltimore). 2024 Jun 7;103(23):e38504. doi: 10.1097/MD.0000000000038504.

DOI:10.1097/MD.0000000000038504
PMID:38847686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11155566/
Abstract

OBJECTIVE

To systematically evaluate the efficacy of Er Chen Tang in the adjuvant treatment of obesity.

METHODS

A computerized search of databases such as CNKI, Wanfang, Wipro, EMBase, Web of Science, PubMed, and Cochrane Library was performed to collect randomized controlled trials on the application of Er Cheng Tang for the treatment of obesity and to track the references included in the literature, with a timeframe from the establishment of the library to October 2023 for the searches. After selection of trials, extraction of information and assessment of methodological quality were done independently by 2 evaluators, meta-analysis was performed using RevMan 5.3 software and the quality of evidence was evaluated using the Cochrane system.

RESULTS

Six studies were included, with a total of 438 study participants. They were randomized into trial and control groups. The total cholesterol, triglyceride, low-density lipoprotein cholesterol, body mass index, and visceral fat area values before treatment were compared between the 2 groups, and the differences were not statistically significant (all P > .05). After treatment, the indicators of the experimental group were significantly better than those of the control group, and the differences were all statistically significant (P < .05).

CONCLUSION

The adjuvant treatment of obesity with Er Chen Tang can improve the symptoms faster and is favorable to the reduction of various risk indicators. However, due to the lack of high-quality literature, the theoretical support of large-sample double-blind randomized trials is still needed in the future.

摘要

目的

系统评价二陈汤辅助治疗肥胖症的疗效。

方法

计算机检索中国知网、万方、维普、Embase、Web of Science、PubMed、Cochrane Library 等数据库，收集二陈汤治疗肥胖症的随机对照试验，同时追溯纳入文献的参考文献，检索时限均从建库起至 2023 年 10 月。对纳入的试验进行筛选、资料提取和方法学质量评价后，采用 RevMan 5.3 软件进行 Meta 分析，并采用 Cochrane 系统评价方法评价证据质量。

结果

共纳入 6 个研究，总计 438 例研究对象。按随机分组方法分为试验组和对照组，比较 2 组治疗前后的总胆固醇、三酰甘油、低密度脂蛋白胆固醇、体质量指数、内脏脂肪面积，差异均无统计学意义（均 P>.05）。治疗后，试验组各项指标均明显优于对照组，差异均有统计学意义（均 P<.05）。

结论

二陈汤辅助治疗肥胖症可更快改善症状，有利于降低各项风险指标。但由于高质量文献缺乏，未来仍需要大样本、双盲、随机临床试验的理论支持。

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