补阳还五汤（补阳还五汤）治疗血管性痴呆患者的疗效和安全性：系统评价和荟萃分析方案。
Efficacy and safety of Buyang Huanwu-Tang (Boyang Hwano-Tang) in patients with vascular dementia: A protocol of systematic review and meta analysis.
机构信息
College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea.
Department of Neuropsychiatry of Korean Medicine, Pohang Korean Medicine Hospital, Daegu Haany University, Pohang.
出版信息
Medicine (Baltimore). 2021 May 28;100(21):e25886. doi: 10.1097/MD.0000000000025886.
BACKGROUND
Vascular dementia (VaD) is the second most common type of dementia; it has a significant impact on patients and exerts a great social and economic burden. However, there has been no comprehensive systematic review assessing the efficacy and safety of Buyang Huanwu-Tang (Boyang Hwano-Tang, BHT) for VaD. Therefore, this protocol was developed to conduct a comprehensive systematic review and meta-analysis to evaluate the effectiveness and safety of BHT in the treatment of VaD.
METHODS
We will perform a comprehensive electronic search including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database, Cumulative Index to Nursing and Allied Health Literature, PsycARTICLES, Oriental Medicine Advanced Searching Integrated System, Korean Studies Information Service System, Research Information Service System, Korean Medical Database, KMbase, National Digital Science Library, China National Knowledge Infrastructure, Wanfang database, VIP database, Citation Information by NII, and other sources from their inception to November 25, 2020. This systematic review will include only randomized controlled clinical trials of BHT for VaD. The main outcomes will include the Mini-Mental State Examination, Montreal Cognitive Assessment, and Revised Hasegawa's Dementia Scale. Two researchers will independently conduct study selection, data extraction, and appraise the quality and risk of bias of the included studies. A meta-analysis will be conducted using Review Manager version 5.4. The evidence quality of each outcome will be appraised according to the Grades of Recommendation, Assessment, Development, and Evaluation.
RESULTS
This study will provide comprehensive understanding of the efficacy and safety of BHT for the treatment of VaD.
CONCLUSIONS
The findings of this study will provide reliable evidence for clinical application and further study of BHT for VaD.
ETHICS AND DISSEMINATION
Ethical approval is not required because individual patient data will not be included in this study. The study findings will be disseminated through conference presentations.
OSF REGISTRATION DOI
10.17605/OSF.IO/NDYGP.
背景
血管性痴呆（VaD）是第二常见的痴呆类型；它对患者有重大影响，并造成了巨大的社会和经济负担。然而，目前还没有全面的系统评价评估补阳还五汤（Buyang Huanwu-Tang，BHT）治疗 VaD 的疗效和安全性。因此，本研究旨在进行全面的系统评价和荟萃分析，以评估 BHT 治疗 VaD 的有效性和安全性。
方法
我们将进行全面的电子检索，包括 MEDLINE、EMBASE、Cochrane 中央对照试验注册库、补充和综合医学数据库、护理学及相关健康文献累积索引、PsycARTICLES、东方医学高级检索系统、韩国研究信息服务系统、研究信息服务系统、韩国医学数据库、KMbase、国家数字科学图书馆、中国国家知识基础设施、万方数据库、维普数据库、日本科学技术振兴机构学术数据库以及其他来源，检索时间从建库至 2020 年 11 月 25 日。本系统评价将仅纳入补阳还五汤治疗 VaD 的随机对照临床试验。主要结局指标将包括简易精神状态检查、蒙特利尔认知评估和修订后的长谷川痴呆量表。两名研究人员将独立进行研究选择、数据提取，并评价纳入研究的质量和偏倚风险。使用 Review Manager 5.4 进行荟萃分析。根据推荐、评估、制定和评价分级标准对每个结局的证据质量进行评价。
结果
本研究将全面了解补阳还五汤治疗 VaD 的疗效和安全性。
结论
本研究的结果将为补阳还五汤治疗 VaD 的临床应用和进一步研究提供可靠的证据。
伦理和传播
由于本研究不包括个体患者数据，因此不需要伦理批准。研究结果将通过会议报告进行传播。
OSF 注册 DOI：10.17605/OSF.IO/NDYGP。
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