Department of General Surgery, Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu Province, China.
Department of Ophthalmology, Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu Province, China.
Medicine (Baltimore). 2024 Jun 7;103(23):e38466. doi: 10.1097/MD.0000000000038466.
Sclerosing angiomatoid nodular transformation (SANT) of the spleen is an uncommon benign vascular lesion with an obscure etiology. It predominantly affects middle-aged women and presents with nonspecific clinical signs, making preoperative diagnosis challenging. The definitive diagnosis of SANT relies on pathological examination following splenectomy. This study aims to contribute to the understanding of SANT by presenting a case series and reviewing the literature to highlight the clinical presentation, diagnostic challenges, and treatment outcomes.
In this retrospective study, we analyzed the clinical data of 3 patients with confirmed SANT admitted from November 2013 to October 2023. The cases include a 25-year-old male, a 15-year-old female, and a 39-year-old male, each with a splenic mass.
All of the three cases were treated by laparoscopic splenectomy (LS). Pathological examination confirmed SANT in all cases.
No recurrence or metastasis was observed during a 10-year follow-up for the first 2 cases, and the third case showed no abnormalities at 2 months postoperatively. Despite its rarity, SANT is a significant condition due to its potential for misdiagnosis and the importance of distinguishing it from malignant lesions. The study underscores the utility of LS as a safe and effective treatment option.
SANT is a rare benign tumor of the spleen, and the preoperative diagnosis of whom is challenging. LS is a safe and effective treatment for SANT, with satisfactory surgical outcomes and favorable long-term prognosis on follow-up. The study contributes to the limited body of research on this rare condition and calls for larger studies to validate these findings and improve clinical management.
脾脏硬化性血管样结节性转化（SANT）是一种少见的良性血管性病变，病因不明。它主要影响中年女性，表现为非特异性临床症状，术前诊断具有挑战性。SANT 的明确诊断依赖于脾切除术后的病理检查。本研究旨在通过病例系列和文献复习，为 SANT 的理解做出贡献，强调其临床表现、诊断挑战和治疗结果。
在这项回顾性研究中，我们分析了 2013 年 11 月至 2023 年 10 月期间确诊为 SANT 的 3 例患者的临床资料。这 3 例患者分别为 1 例 25 岁男性、1 例 15 岁女性和 1 例 39 岁男性，均存在脾脏肿块。
所有 3 例患者均接受了腹腔镜脾切除术（LS）治疗。所有病例的病理检查均证实为 SANT。
前 2 例患者在 10 年随访中未观察到复发或转移，第 3 例患者在术后 2 个月时无异常。尽管 SANT 罕见，但由于其误诊的可能性以及将其与恶性病变区分开来的重要性，仍然是一种重要的疾病。本研究强调了 LS 作为一种安全有效的治疗选择的效用。
SANT 是一种罕见的脾脏良性肿瘤，术前诊断具有挑战性。LS 是 SANT 的安全有效治疗方法，手术结果满意，随访时长期预后良好。本研究为这一罕见疾病的有限研究做出了贡献，并呼吁进行更大规模的研究，以验证这些发现并改善临床管理。
