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How can polymyxin B be dosed based on current pharmacokinetic knowledge?

作者信息

Chen Huadong, Zhang Zhenjiao, Yu Zhenwei

机构信息

Pharmacy Department, Affiliated Dongyang Hospital of Wenzhou Medical University, Wuning West Road 60th, Dongyang, 322100, Zhejiang, China.

Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

出版信息

Eur J Clin Pharmacol. 2024 Sep;80(9):1421-1423. doi: 10.1007/s00228-024-03708-3. Epub 2024 Jun 7.

DOI:10.1007/s00228-024-03708-3
PMID:38847855
Abstract
摘要

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How can polymyxin B be dosed based on current pharmacokinetic knowledge?基于当前的药代动力学知识，多粘菌素B应如何给药？
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Reply to Pai.回复派伊。
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引用本文的文献

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Antimicrob Agents Chemother. 2025 Apr 2;69(4):e0185924. doi: 10.1128/aac.01859-24. Epub 2025 Mar 6.

本文引用的文献

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Efficacy and safety of ramucirumab for gastric or gastro-esophageal junction adenocarcinoma: a systematic review and meta-analysis.雷莫芦单抗治疗胃或胃食管结合部腺癌的疗效和安全性：系统评价和荟萃分析。
Eur J Clin Pharmacol. 2024 Nov;80(11):1697-1714. doi: 10.1007/s00228-024-03734-1. Epub 2024 Aug 5.
2
Daily fluid intake as a novel covariate affecting the population pharmacokinetics of polymyxin B in patients with sepsis.每日液体摄入量作为影响脓毒症患者多粘菌素 B 群体药代动力学的新协变量。
Int J Antimicrob Agents. 2024 Mar;63(3):107099. doi: 10.1016/j.ijantimicag.2024.107099. Epub 2024 Jan 26.
3
Population pharmacokinetics of polymyxin B in patients with liver dysfunction.
肝功能障碍患者中多黏菌素 B 的群体药代动力学。
Br J Clin Pharmacol. 2023 Dec;89(12):3561-3572. doi: 10.1111/bcp.15855. Epub 2023 Aug 8.
4
A population pharmacokinetic model of polymyxin B based on prospective clinical data to inform dosing in hospitalized patients.基于前瞻性临床数据的多粘菌素 B 群体药代动力学模型，用于指导住院患者的给药剂量。
Clin Microbiol Infect. 2023 Sep;29(9):1174-1181. doi: 10.1016/j.cmi.2023.05.018. Epub 2023 May 20.
5
Population Pharmacokinetic Modeling Using Polymyxin B Free Plasma Concentrations From Published Reports and Evaluation of Dosage Regimens Based on Monte Carlo Simulation in Critically Ill Patients.应用文献中报道的多黏菌素 B 游离血浆浓度进行群体药代动力学建模，并基于蒙特卡罗模拟对危重症患者的给药方案进行评价。
J Clin Pharmacol. 2023 Sep;63(9):1036-1044. doi: 10.1002/jcph.2261. Epub 2023 May 25.
6
Population pharmacokinetic analysis and dosing optimization of polymyxin B in critically ill patients.重症患者多黏菌素B的群体药代动力学分析及给药方案优化
Front Pharmacol. 2023 Mar 29;14:1122310. doi: 10.3389/fphar.2023.1122310. eCollection 2023.
7
Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B, endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.《多黏菌素 B 治疗药物监测中国专家共识》，由上海市医学会感染与化疗专科分会和中国药理学会治疗药物监测研究专业委员会共同制订。
J Zhejiang Univ Sci B. 2023 Feb 15;24(2):130-142. doi: 10.1631/jzus.B2200466.
8
Comparative polymyxin B pharmacokinetics in critically ill patients with renal insufficiency and in continuous veno-venous hemodialysis.肾功能不全的重症患者与持续静静脉血液透析患者中多粘菌素B的药代动力学比较
Eur J Clin Pharmacol. 2023 Jan;79(1):79-87. doi: 10.1007/s00228-022-03415-x. Epub 2022 Nov 15.
9
Pharmacokinetics and pharmacodynamics of polymyxin B and proposed dosing regimens in elderly patients with multi-drug-resistant Gram-negative bacterial infections.多粘菌素B在老年多重耐药革兰氏阴性菌感染患者中的药代动力学、药效学及拟用给药方案
Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106693. doi: 10.1016/j.ijantimicag.2022.106693. Epub 2022 Nov 11.
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Population pharmacokinetic analysis, renal safety, and dosing optimization of polymyxin B in lung transplant recipients with pneumonia: A prospective study.肺移植受者肺炎患者多粘菌素B的群体药代动力学分析、肾脏安全性及给药优化：一项前瞻性研究
Front Pharmacol. 2022 Oct 13;13:1019411. doi: 10.3389/fphar.2022.1019411. eCollection 2022.