Zhai Wei, Gao Jie, Qin Wen, Xu Yuerong
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, the Fourth Military Medical University, Xi'an, China.
Stem Cell Rev Rep. 2024 Aug;20(6):1521-1531. doi: 10.1007/s12015-024-10731-5. Epub 2024 Jun 7.
Non-coding RNA has many types which has rich functions and plays an important role in the study of basic molecular mechanisms. Many non-coding RNA have important implications for pluripotent stem cells and embryonic stem cells. It has been found to affect the self-renewal and osteogenesis of many types of stem cells. They have also been found to regulate stem cell proliferation and induct bone differentiation. Periodontal ligament stem cells are essential for the regeneration of periodontal tissue. In recent years, in the field of stomatology, studies have found that many non-coding RNA also have significant regulatory effects on the proliferation and differentiation of periodontal stem cells and may become potential therapeutic targets for many common periodontal diseases such as periodontitis, bone/tooth/soft tissue loss and orthodontic treatment. Therefore, we summarized the current research status of non-coding RNA in the field of molecular mechanism of periodontal ligament stem cells and prospected its future progress.
非编码RNA有多种类型，功能丰富，在基础分子机制研究中发挥着重要作用。许多非编码RNA对多能干细胞和胚胎干细胞具有重要意义。已发现其影响多种类型干细胞的自我更新和成骨作用。还发现它们可调节干细胞增殖并诱导骨分化。牙周膜干细胞对牙周组织再生至关重要。近年来，在口腔医学领域，研究发现许多非编码RNA对牙周干细胞的增殖和分化也具有显著的调节作用，可能成为牙周炎、骨/牙/软组织丧失及正畸治疗等多种常见牙周疾病的潜在治疗靶点。因此，我们总结了非编码RNA在牙周膜干细胞分子机制领域的研究现状，并对其未来进展进行了展望。
