Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
Networking Research Center on Neurodegenerative Diseases - CIBERNED, Instituto de Salud Carlos III, Madrid, Spain.
J Alzheimers Dis. 2024;100(1):41-43. doi: 10.3233/JAD-240055.
This commentary provides an in-depth analysis of a recently published systematic review on 'Biomarkers of Tau Pathology in Alzheimer's Disease', elucidating insights into its implications for the field. This meta-analysis highlights the potential of plasma and CSF p-tau 181/231 as promising, non-invasive, and cost-effective diagnostic tools for patients suffering from AD continuum. The study comprehensively reviews the diagnostic potential of these p-tau isoforms, shedding light on their role in the precision diagnosis of Alzheimer's disease. Here we discuss the significance of these findings and the methodological nuances, emphasizing broader implications for advancing personalized medicine in neurodegenerative disorders.
这篇评论深入分析了最近发表的一篇关于“阿尔茨海默病中 Tau 病理学的生物标志物”的系统评价,阐明了其对该领域的意义。这项荟萃分析强调了血浆和 CSF p-tau 181/231 作为有前途的、非侵入性和具有成本效益的 AD 连续谱患者诊断工具的潜力。该研究全面综述了这些 p-tau 同工型的诊断潜力,揭示了它们在阿尔茨海默病精准诊断中的作用。在这里,我们讨论了这些发现的意义和方法学细节,强调了它们对推进神经退行性疾病个性化医学的更广泛影响。