State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
School of Ophthalmology and Optometry, School of Biomedical Engineering, State Key Laboratory of Ophthalmology, Optometry, and Vision Science, Wenzhou Medical University, Wenzhou 325027, China.
ACS Nano. 2024 Jun 18;18(24):15681-15694. doi: 10.1021/acsnano.4c01818. Epub 2024 Jun 7.
The prolonged wound-healing process caused by pathogen infection remains a major public health challenge. The developed electrical antibiotic administration typically requires metal electrodes wired to a continuous power supply, restricting their use beyond clinical environments. To obviate the necessity for antibiotics and an external power source, we have developed a wearable synergistic electroceutical device composed of an air self-charging Zn battery. This battery integrates sustained tissue regeneration and antibacterial modalities while maintaining more than half of the initial capacity after ten cycles of chemical charging. In vitro bacterial/cell coculture with the self-charging battery demonstrates inhibited bacterial activity and enhanced cell function by simulating the endogenous electric field and dynamically engineering the microenvironment with released chemicals. This electroceutical device provides accelerated healing of a bacteria-infected wound by stimulating angiogenesis and modulating inflammation, while effectively inhibiting bacterial growth at the wound site. Considering the simple structure and easy operation for long-term treatment, this self-charging electroceutical device offers great potential for personalized wound care.
由病原体感染引起的漫长伤口愈合过程仍然是一个主要的公共卫生挑战。已开发的电抗生素给药系统通常需要金属电极连接到连续电源，这限制了它们在临床环境之外的使用。为了避免使用抗生素和外部电源，我们开发了一种由自充电 Zn 电池组成的可穿戴协同电疗装置。该电池集成了持续的组织再生和抗菌模式，同时在经过十次化学充电循环后仍保持初始容量的一半以上。带自充电电池的体外细菌/细胞共培养通过模拟内源性电场并利用释放的化学物质动态工程化微环境，证明了抑制细菌活性和增强细胞功能。这种电疗装置通过刺激血管生成和调节炎症来加速感染细菌的伤口愈合，同时有效抑制伤口部位的细菌生长。考虑到其简单的结构和便于长期治疗的操作，这种自充电电疗装置为个性化伤口护理提供了巨大的潜力。
