同卵双胞胎的工作机制：PLD3/4 的结构揭示了溶酶体核酸降解的机制。
Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown.
机构信息
Structural Biology, Max Delbrück Center for Molecular Medicine (MDC), 13125 Berlin, Germany; Institute for Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Biochemical Institute, Christian-Albrechts-University of Kiel, Kiel, Germany.
出版信息
Structure. 2024 Jun 6;32(6):645-647. doi: 10.1016/j.str.2024.05.002.
Phospholipase D (PLD) family proteins degrade phospholipids and nucleic acids. In the current issue of Structure, Yuan et al. report crystal structures of lysosomal PLD3 and PLD4 with and without a single-stranded DNA substrate. Their manuscript reveals a catalytic ping-pong mechanism and explains how disease-associated mutations compromise PLD3/4 function.
磷酸酯酶 D（PLD）家族蛋白可降解磷脂和核酸。在本期的《结构》杂志中，袁等人报道了溶酶体 PLD3 和 PLD4 与其单链 DNA 底物结合和未结合的晶体结构。他们的论文揭示了一种催化乒乓机制，并解释了与疾病相关的突变如何影响 PLD3/4 的功能。
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